Results 121 to 130 of about 17,799,762 (307)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Turbulence link to L-mode, I-mode, and H-mode confinement in the DIII-D tokamak

open access: yesNuclear Fusion
Understanding the physics of low-confinement (L-), improved-confinement (I-), and high-confinement (H-) modes is critical for fusion reactors. The finding herein reports observations of two types of turbulence coexisting near the L-mode edge, one ...
J. Chen   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Transition to H-Mode by Energetic Electrons

open access: yes, 1992
Effect of the electron loss due to the toroidal ripple on an H-mode transition is studied. When energetic electrons exist in tokamaks, e.g. in the case of the current drive by lower hybrid (LH) waves, the edge electric field can show the bifurcation to ...
Itoh, S.-I., Itoh, K.
core   +1 more source

EFFECTS OF A DEEP MIXED SHELL ON SOLARg-MODES,p-MODES, AND NEUTRINO FLUX

open access: yesThe Astrophysical Journal, 2009
A mixed-shell model that reflects g-modes away from the Sun's center is developed further by calibrating its parameters and evaluating a mixing mechanism: buoyancy. The shell roughly doubles g-mode oscillation periods and would explain why there is no definitive detection of their periods. But the shell has only minor effects on most p-modes. The model
openaire   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Erzählte Mode

open access: yes
Erzählte Mode zeichnet sich durch historische, medienspezifische, regionale, ästhetische und theoretische Charakteristiken aus. Dieser Band versammelt multi- und transdisziplinäre Analysen, die einen Eindruck von dem Facettenreichtum sowie den ...

core   +1 more source

Određenje i modeli samoregulacije učenja [PDF]

open access: yes, 2019
U ovom poglavlju najprije su opisani neki od najistaknutijih suvremenih modela samoreguliranog učenja kao što su modeli Barryja Zimmermana, Paula Pintricha i Monique Boekaerts. Jedan od novijih modela, koji je također opisan u poglavlju, jest i model proaktivne i obrambene samoregulacije Darka Lončarića. Nakon toga, predložen je integrativni model koji
openaire  

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