Results 1 to 10 of about 10,069 (188)
Protein embeddings and deep learning predict binding residues for various ligand classes
Scientific Reports, 2021 One important aspect of protein function is the binding of proteins to ligands, including small molecules, metal ions, and macromolecules such as DNA or RNA. Despite decades of experimental progress many binding sites remain obscure.
Maria Littmann +4 more
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Embeddings from deep learning transfer GO annotations beyond homology
Scientific Reports, 2021 Knowing protein function is crucial to advance molecular and medical biology, yet experimental function annotations through the Gene Ontology (GO) exist for fewer than 0.5% of all known proteins.
Maria Littmann +4 more
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TMbed: transmembrane proteins predicted through language model embeddings
BMC Bioinformatics, 2022 Background Despite the immense importance of transmembrane proteins (TMP) for molecular biology and medicine, experimental 3D structures for TMPs remain about 4–5 times underrepresented compared to non-TMPs.
Michael Bernhofer, Burkhard Rost
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Rendering protein mutation movies with MutAmore
BMC Bioinformatics, 2023 Background The success of AlphaFold2 in reliable protein three-dimensional (3D) structure prediction, assists the move of structural biology toward studies of protein dynamics and mutational impact on structure and function.
Konstantin Weissenow, Burkhard Rost
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Variant effect predictions capture some aspects of deep mutational scanning experiments
BMC Bioinformatics, 2020 Background Deep mutational scanning (DMS) studies exploit the mutational landscape of sequence variation by systematically and comprehensively assaying the effect of single amino acid variants (SAVs; also referred to as missense mutations, or non ...
Jonas Reeb, Theresa Wirth, Burkhard Rost
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Domain loss enabled evolution of novel functions in the snake three-finger toxin gene superfamily
Nature Communications, 2023 Three-finger toxins (3FTXs) are a functionally diverse family of toxins, apparently unique to venoms of caenophidian snakes. Although the ancestral function of 3FTXs is antagonism of nicotinic acetylcholine receptors, redundancy conferred by the ...
Ivan Koludarov +6 more
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Effect of health outcome on economic growth in sub-Saharan Africa: a system generalized method of moment approach [PDF]
Journal of Economics and Development, 2021 Purpose – Some progress have been made over time in improving health conditions in Sub-Saharan Africa (SSA). There are, however, contradicting reports on the relationship between health outcomes and economic growth in the region.
Sakiru Oladele Akinbode +3 more
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BMC Bioinformatics, 2020 Background Any two unrelated people differ by about 20,000 missense mutations (also referred to as SAVs: Single Amino acid Variants or missense SNV). Many SAVs have been predicted to strongly affect molecular protein function.
Jiajun Qiu +2 more
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Education and inclusive growth in West Africa [PDF]
Journal of Economics and Development, 2020 Purpose – Many West African countries face the challenge of growth inclusiveness. The region is also facing challenges of equipping its teeming population with high-quality skills despite many reforms and initiatives introduced in the past.
Oluwatosin Adeniyi +2 more
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The cost of mass gatherings during a pandemic
SSM: Population Health, 2023 In June 2020, the U.S., unlike other regions of the world, faced a surge in cases of COVID-19. Immediately prior to this wave of cases, the largest mass protests in U.S. history took place. We show that when holding other factors constant, COVID-19 cases
Ludovic Phalippou, Dayin Zhang
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