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Protein Structure Prediction in Drug Discovery [PDF]
Biomolecules, 2023 When the results of DeepMind’s AlphaFold2 at CASP were announced in 2020, the scientific world was so amazed by how effectively it performed that “it will change everything” became the motto for this revolution [...]
Alessandro Paiardini
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Conformational ensembles for protein structure prediction [PDF]
Scientific ReportsAcquisition of conformational ensembles for a protein is a challenging task, which is actually involving to the solution for protein folding problem and the study of intrinsically disordered protein.
Jiaan Yang +9 more
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Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields, including biochemistry, medicine, physics, mathematics, and computer science.
Bin Huang +10 more
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Protein Structure Prediction [PDF]
, 2009 Práce popisuje prostorovou strukturu molekul bílkovin a databází uchovávajících representace této struktury, či její hierarchické klasifikace. Je poskytnut přehled současných metod výpočetní predikce struktury bílkovin, přičemž největší pozornost je ...
Tuček, Jaroslav
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Protein Structure Prediction [PDF]
Biophysical Journal, 2008 Protein structure prediction has matured over the past few years to the point that even fully automated methods can provide reasonably accurate three-dimensional models of protein structures. However, until now it has not been possible to develop programs able to perform as well as human experts, who are still capable of systematically producing better
AlLazikani B, Hill EE, Morea V
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Deep template-based protein structure prediction.
PLoS Computational Biology, 2021 MotivationProtein structure prediction has been greatly improved by deep learning, but most efforts are devoted to template-free modeling. But very few deep learning methods are developed for TBM (template-based modeling), a popular technique for protein
Fandi Wu, Jinbo Xu
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Protein structure prediction [PDF]
International Journal of Modern Physics B, 2018 Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction.
Haiyou, Deng, Ya, Jia, Yang, Zhang
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How long is a piece of loop? [PDF]
PeerJ, 2013 Loops are irregular structures which connect two secondary structure elements in proteins. They often play important roles in function, including enzyme reactions and ligand binding. Despite their importance, their structure remains difficult to predict.
Yoonjoo Choi +2 more
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TMbed: transmembrane proteins predicted through language model embeddings
BMC Bioinformatics, 2022 Background Despite the immense importance of transmembrane proteins (TMP) for molecular biology and medicine, experimental 3D structures for TMPs remain about 4–5 times underrepresented compared to non-TMPs.
Michael Bernhofer, Burkhard Rost
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Computational Approach for Protein Structure Prediction [PDF]
Healthcare Informatics Research, 2013 ObjectivesTo predict the structure of protein, which dictates the function it performs, a newly designed algorithm is developed which blends the concept of self-organization and the genetic algorithm.MethodsAmong many other approaches, genetic algorithm ...
Amouda Venkatesan +4 more
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