Results 11 to 20 of about 410,461 (311)
Protein Structure Prediction in Drug Discovery [PDF]
Biomolecules, 2023 When the results of DeepMind’s AlphaFold2 at CASP were announced in 2020, the scientific world was so amazed by how effectively it performed that “it will change everything” became the motto for this revolution [...]
Alessandro Paiardini
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Conformational ensembles for protein structure prediction [PDF]
Scientific ReportsAcquisition of conformational ensembles for a protein is a challenging task, which is actually involving to the solution for protein folding problem and the study of intrinsically disordered protein.
Jiaan Yang +9 more
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Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields, including biochemistry, medicine, physics, mathematics, and computer science.
Bin Huang +10 more
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The Assessment of Methods for Protein Structure Prediction
, 2007 Methods for protein structure prediction are flourishing and becoming widely available to both experimentalists and computational biologists. But, how good are they? What is their range of applicability and how can we know which method is better suited for the task at hand?
TRAMONTANO, ANNA +3 more
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The breakthrough in protein structure prediction [PDF]
Biochemical Journal, 2021 Proteins are the essential agents of all living systems. Even though they are synthesized as linear chains of amino acids, they must assume specific three-dimensional structures in order to manifest their biological activity. These structures are fully specified in their amino acid sequences — and therefore in the nucleotide sequences of their genes ...
Andrei N. Lupas +5 more
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Deep template-based protein structure prediction.
PLoS Computational Biology, 2021 MotivationProtein structure prediction has been greatly improved by deep learning, but most efforts are devoted to template-free modeling. But very few deep learning methods are developed for TBM (template-based modeling), a popular technique for protein
Fandi Wu, Jinbo Xu
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How long is a piece of loop? [PDF]
PeerJ, 2013 Loops are irregular structures which connect two secondary structure elements in proteins. They often play important roles in function, including enzyme reactions and ligand binding. Despite their importance, their structure remains difficult to predict.
Yoonjoo Choi +2 more
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TMbed: transmembrane proteins predicted through language model embeddings
BMC Bioinformatics, 2022 Background Despite the immense importance of transmembrane proteins (TMP) for molecular biology and medicine, experimental 3D structures for TMPs remain about 4–5 times underrepresented compared to non-TMPs.
Michael Bernhofer, Burkhard Rost
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Protein structure prediction [PDF]
International Journal of Modern Physics B, 2018 Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction.
Haiyou, Deng, Ya, Jia, Yang, Zhang
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Computational Approach for Protein Structure Prediction [PDF]
Healthcare Informatics Research, 2013 ObjectivesTo predict the structure of protein, which dictates the function it performs, a newly designed algorithm is developed which blends the concept of self-organization and the genetic algorithm.MethodsAmong many other approaches, genetic algorithm ...
Amouda Venkatesan +4 more
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