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Advances in protein tertiary structure prediction
Biomedical and Biotechnology Research Journal, 2018 Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity.
Tayebeh Farhadi
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BMC Bioinformatics, 2020 Background Whenever suitable template structures are not available, usage of fragment-based protein structure prediction becomes the only practical alternative as pure ab initio techniques require massive computational resources even for very small ...
Jad Abbass, Jean-Christophe Nebel
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Sisyphus and prediction of protein structure [PDF]
Bioinformatics, 1997 The problem of predicting protein structure from the sequence remains fundamentally unsolved despite more than three decades of intensive research effort. However, new and promising methods in three-dimensional (3D), 2D and 1D prediction have reopened the field.
Burkhard Rost, Seán I. O'Donoghue
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Progress in protein structure prediction? [PDF]
Trends in Biochemical Sciences, 1993 Prediction of protein secondary structure is an old problem and progress has been slow. Recently, spectacular success has been claimed in the blind prediction of the catalytic subunit of the cAMP-dependent protein kinase. When predictions in this and other test cases are assessed critically, some claims of prediction success turn out to be exaggerated,
ROST, B. +2 more
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Structure Prediction of Membrane Proteins
Genomics, Proteomics & Bioinformatics, 2004 Abstract There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding of the function of an MP and ...
Zhou, Chunlong, Zheng, Yao, Zhou, Yan
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Protein 3D structure prediction Using Homology Method [PDF]
Fayoum University Journal of EngineeringFor decades, the prediction of protein three-dimensional structure from amino acid sequence has been a magnificent challenge problem in computational biophysics.
Rania Abul Seoud +2 more
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Deep learning methods in protein structure prediction
Computational and Structural Biotechnology Journal, 2020 Protein Structure Prediction is a central topic in Structural Bioinformatics. Since the ’60s statistical methods, followed by increasingly complex Machine Learning and recently Deep Learning methods, have been employed to predict protein structural ...
Mirko Torrisi +2 more
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Recent Progress of Protein Tertiary Structure Prediction
MoleculesThe prediction of three-dimensional (3D) protein structure from amino acid sequences has stood as a significant challenge in computational and structural bioinformatics for decades.
Qiqige Wuyun +7 more
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Accurate protein structure prediction with hydroxyl radical protein footprinting data
Nature Communications, 2021 Mass spectrometry-based covalent labeling techniques such as hydroxyl radical protein footprinting (HRPF) provide information about protein tertiary structures.
Sarah E. Biehn, Steffen Lindert
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PS4: a next-generation dataset for protein single-sequence secondary structure prediction
BioTechniques, 2023 Protein secondary structure prediction is a subproblem of protein folding. A light-weight algorithm capable of accurately predicting secondary structure from only the protein residue sequence could provide useful input for tertiary structure prediction ...
Omar Peracha
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