Results 141 to 150 of about 11,267 (189)

I12 The role of the cerebellum in juvenile huntington’s disease (JHD)

Journal of Neurology, Neurosurgery & Psychiatry, 2016
Background The cerebellum is integrated structurally and functionally with the striatum with the anterior lobe having input into the indirect pathway of the striatum – the pathway responsible for movement inhibition, and the pathway affected most by HD. In JHD, hyper-connectivity of the cerebellum could lead to the hypokinetic state seen in JHD. Aim
Peggy Nopoulos, Jessica Lee, Eric Epping, Erin Martin, Kathy Mathews, Patricia Espe-Pfeiffer, Vincent Magnotta   +6 more
openaire   +1 more source

Crystal supramolecular motifs in trimorphs of [Fe(phen)3] I12

CrystEngComm, 2000
We describe three different crystals, 1A, 1B, 1C, with the composition [Fe(phen)3] I12 (phen = 1,10-phenanthroline). They are crystallised from solutions containing [Fe(phen)3] I2 plus I2, but there is not complete reproducibility in the crystallisation experiments and it appears that kinetic crystallisation is responsible for the formation of these ...
Caitlin Horn, Marcia Scudder, Ian Dance
openaire   +1 more source

Abstract I12: CD40 immunotherapy for pancreatic cancer

Cancer Research, 2019
Abstract CD40 is a cell-surface member of the TNF receptor superfamily that upon activation can license dendritic cells (DC) to promote antitumor T-cell activation and re-educate macrophages to destroy tumor stroma. Mechanistically, the combination of chemotherapy followed by CD40 mAb functions as an “in situ” vaccine; in addition ...
openaire   +1 more source

I12 Repositioning andrographolide for airway inflammation: Mapping its mechanistic networks

Biochemical Pharmacology, 2017
Inhaled corticosteroid is the first-line controller for asthma and COPD. However, about 10% of the asthmatics (severe/refractory asthma) and most of the COPD patients are resistant to the beneficial effects of corticosteroids. There is a pressing unmet medical need to develop novel therapeutic agents to restore corticosteroid efficacy in affected ...
Fred Wong, W.S. Daniel Tan, Wupeng Liao
openaire   +1 more source

Residual stress measurement on the I12 JEEP beamline at Diamond Light Source

Diamond Light Source Proceedings, 2010
One of the multiple capabilities of the new Joint Engineering, Environmental and Processing (JEEP) beamline I12 at Diamond Light Source is the set-up for polychromatic high-energy X-ray diffraction for the study of polycrystalline deformation and residual stresses. The results and interpretation of the first experiments carried out on JEEP are reported.
A. M. Korsunsky, X. Song, F. Hofmann, B. Abbey, M. Xie, T. Connolley, C. Reinhard, R. Atwood, L. Connor, M. Drakopoulos   +9 more
openaire   +1 more source

I12 Interferons: Overlooked regulators of innate and adaptive immune responses

Cytokine, 2012
Type I IFNs, that include the IFN- α s and IFN-s, are critical effectors of the host antiviral immune response. Much attention has focused on their direct antiviral effects against viruses in infected tissues, examining specific signaling cascades and effector molecules induced by these IFNs that mediate virus inhibition and protection from infection ...
openaire   +1 more source

I12 | Anthelmintics and ion‐channels

Journal of Veterinary Pharmacology and Therapeutics, 2023
openaire   +1 more source

2A2-I12 RoboLDK2006 : Contest of Life with Robot

The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec), 2007
Yuki Nakagawa, Dairoku Sekiguchi, Takasuke Sonoyama, Taisei Tanaka, Tsutomu Toyama, Masao Mukaidono, Fuminori Yamasaki, Hideaki Hayashi   +7 more
openaire   +1 more source

I12 Next generation sequencing

Reproductive BioMedicine Online, 2013
D. Wells, K. Kaur, E. Fragouli, S. Munné   +3 more
openaire   +1 more source

Overdiagnosis of Idiopathic Intracranial Hypertension (IIH) (I12-3B)

Neurology, 2015
Adeniyi Fisayo, Valerie Biousse, Nancy Newman, Beau Bruce   +3 more
openaire   +1 more source