Results 31 to 40 of about 2,819 (176)

Effect of Hypophysectomy on the Intrathyroidal Metabolism of I131

Experimental Biology and Medicine, 1951
SummaryHypphysectomy reduced but did not abolish the over-all conversion of I113 into labeled thyroxine.
A, ALBERT, N, LORENZ
openaire   +2 more sources

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, Volume 183, Issue 17, Page 5372-5388, September 2026.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Inhibition of Degradation of Insulin-I131 in vivo.

Experimental Biology and Medicine, 1954
SummaryInsulin-I131 degradation in rats in vivo was not inhibited by the administration of zinc in the diet, or by treatment with the substance, polyphloretin phosphate. Marked inhibition was obtained by the intravenous or prolonged oral administration of 5-isopropylidene-2,4-dithiohydantoin and it was suggested that this may explain the protection ...
N J, ELGEE, R H, WILLIAMS
openaire   +2 more sources

Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood

International Journal of Endocrinology, 2016
Introduction. Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods.
Melanie Metallo, Lelia Groza, Laurent Brunaud, Marc Klein, Georges Weryha, Eva Feigerlova   +5 more
doaj   +1 more source

I-131 Avid Versus FDG avid Loco-Regional Recurrent Differentiated Thyroid Carcinoma;Clinic-Pathological, Diagnostic & Therapy Outcome Differences [PDF]

Egyptian Journal of Nuclear Medicine, 2015
Purpose: Toassess the clinic-pathological, diagnostic & therapy outcome differences between I-131 avid and FDG avid loco-regional recurrence in differentiated thyroid carcinoma (DTC) patients.Materials and methods: 125 patients with pathologically ...
Omnia Talaat
doaj   +1 more source

Application of I131 to Determination of Viral Antibodies

Experimental Biology and Medicine, 1955
SummaryExperiments are described in which preparations of yellow fever virus, Bwamba fever virus and influenza virus were allowed to react with corresponding antisera labeled with radioactive iodine (I131). No significant differences were observed in the activity of the sediments obtained with the first 2 virus systems from those of appropriate ...
D H, CLARKE, F L, BLACK
openaire   +2 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Immunotherapy in Thyroid Cancer: Current Strategies and Challenges

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Thyroid cancer is the most common endocrine malignancy, with an increasing global incidence. Despite advances in conventional treatments, such as surgery, radioactive iodine therapy, and TSH suppression, the management of advanced and aggressive forms, such as anaplastic thyroid carcinoma and refractory differentiated thyroid carcinoma ...
Qian Zhang, Fan Wang, Wenbin Ma, Nan Liu, Yihan Lu, Ping Zhang   +5 more
wiley   +1 more source

Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival

Head &Neck, Volume 48, Issue 3, Page 644-649, March 2026.
ABSTRACT Background Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high‐risk thyroid surgeries. Methods Retrospective study of patients undergoing segmental tracheal resection for thyroid cancer at MD Anderson Cancer Center (2005–2024).
Anastasios Maniakas, David C. Wilde, Isabelle Fournier, Emily K. Hyde, Li Xu, Jennifer R. Wang, Neil D. Gross, Erich M. Sturgis, Victoria Banuchi, Naifa L. Busaidy, Maria E. Cabanillas, Priyanka Iyer, Ramona Dadu, Steven G. Waguespack, Mimi I. Hu, G. Brandon Gunn, Michael Kwon, Salmaan Ahmed, Michelle D. Williams, Mark E. Zafereo   +19 more
wiley   +1 more source