Results 121 to 130 of about 236,407 (329)

Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis

PLoS Genetics, 2016
The phytohormone auxin is a key regulator of plant growth and development. Molecular studies in Arabidopsis have shown that auxin perception and signaling is mediated via TIR1/AFB–Aux/IAA co-receptors that assemble as part of the SCFTIR1/AFB E3 ubiquitin-
M. Dezfulian, Espanta Jalili, D. K. A. Roberto, Britney L. Moss, K. Khoo, J. Nemhauser, W. Crosby   +6 more
semanticscholar   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Insulin autoantibodies as determined by competitive radiobinding assay are positively correlated with impaired beta-cell function — The Ulm-Frankfurt population study [PDF]

, 1991
Out of a random population of 4208 non-diabetic pupils without a family history of Type I diabetes 44 (1.05%) individuals had islet cell antibody (ICA) levels greater or equal to 5 Juvenile Diabetes Foundation (JDF) units. 39 of these ICA-positives could
AC Tarn, AG Ziegler, AG Ziegler, B Kuglin, B Kuglin, B. O. Boehm, BM Dean, C Betterle, E Bonifacio, E. F. Pfeiffer, E. Heinze, GS Eisenbarth, J Bertrams, J Karjalainen, J Karjalainen, J. Seißler, JJ Rood Van, JP Palmer, KM Spencer, M Bergua, M. Glück, MA Atkinson, N. Yassin, P Vardi, S Srikanta, S Srikanta, SA Arslanian, T Wilkin, W. A. Scherbaum, WA Scherbaum   +29 more
core   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Calcium application mitigates salt stress in Date Palm (Phoenix dactylifera L.( offshoots cultivars of Berhi and Sayer

Acta Agriculturae Slovenica, 2016
The effectiveness of exogenous application of calcium in ameliorating the adverse effects of salt stress (15.9 dS m-1) on date palm offshoots (Phoenix dactylifera L. cultivars of Berhi and Sayer) was investigated.
Abbas M. JASIM, Muayed F. ABBAS, Hussein J. SHAREEF   +2 more
doaj   +1 more source

Weighted SPICE: A Unifying Approach for Hyperparameter-Free Sparse Estimation

, 2014
In this paper we present the SPICE approach for sparse parameter estimation in a framework that unifies it with other hyperparameter-free methods, namely LIKES, SLIM and IAA.
Li, Jian, Stoica, Petre, Zachariah, Dave
core   +1 more source

The endophytic bacteria producing IAA (Indole Acetic Acid) in Arachis hypogaea

, 2017
Herlina L, Pukan KK, Mustikaningtyas D. 2017. The endophytic bacteria producing IAA (Indole Acetic Acid) in Arachis hypogaea. Cell Bio Dev 1: 31-35. Endophytic bacteria are bacteria living in plant tissue and forming colony without harms the host.
Lina Herlina, K. K. Pukan, D. Mustikaningtyas   +2 more
semanticscholar   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Effects of Indole-3-Acetic Acid on Germination in Lead Polluted Petri Dish of Citrullus Lanatus (Thunberg) Matsumura and Nakai, Cucurbitaceae [PDF]

, 2015
Watermelon, Citrullus lanatus (Thunberg) Matsumura and Nakai is a tropical fruit vegetable. Indole-3-acetic acid (IAA) is a popular phytohormone while lead (Pb) is a common environmental pollutant in urban and sub-urban centers. C.
Edwin, O. M. (Osawaru), Ogwu, M. C. (Matthew), Osas, A. R. (Aiwansoba)   +2 more
core   +4 more sources

Metarhizium anisopliaeMitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source