Results 141 to 150 of about 190,542 (306)

Data privacy model using blockchain reinforcement federated learning approach for scalable internet of medical things

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract Internet of Medical Things (IoMT) has typical advancements in the healthcare sector with rapid potential proof for decentralised communication systems that have been applied for collecting and monitoring COVID‐19 patient data. Machine Learning algorithms typically use the risk score of each patient based on risk factors, which could help ...
Chandramohan Dhasaratha, Mohammad Kamrul Hasan, Shayla Islam, Shailesh Khapre, Salwani Abdullah, Taher M. Ghazal, Ahmed Ibrahim Alzahrani, Nasser Alalwan, Nguyen Vo, Md Akhtaruzzaman   +9 more
wiley   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6‐related thrombocytopenia

British Journal of Haematology, EarlyView.
Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov, Julia‐Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina‐Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova   +15 more
wiley   +1 more source

A Critical Review of the 2025 RSHE Guidance and Alternative Approach Framed in Safe Uncertainty

Children &Society, EarlyView.
ABSTRACT This policy review critically examines the English government's 2025 statutory guidance on Relationships Education, Relationship and Sex Education and Health Education (RSHE), analysing its educational assumptions, strengths and limitations through the lens of safe uncertainty.
Emily Setty, Jonny Hunt
wiley   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

Multiple global‐change drivers and cascading effects in Mediterranean ecosystems: Lessons from an iconic national park

Conservation Science and Practice, EarlyView.
Mediterranean ecosystems face complex, multi‐trophic impacts from global‐change drivers, yet responses are often studied in isolation. Using the Doñana Protected Area as a case study, we illustrate how anthropogenic pressures on key species like cork oaks and rabbits, as well as increases in species like wild boar and invasive crayfish, lead to ...
Maria Paniw, Duarte S. Viana, Cristina Coccia, Virginia Domínguez‐García, Iñigo Donázar‐Aramendía, Sebastiano de Franciscis, Alberto García‐Rodríguez, Simone Guareschi, Pablo Homet, Jose B. Lanuza, Cosme López‐Calderón, Irene Mendoza, Eva Moracho, Laetitia M. Navarro, Javier Puy, José M. Reyes‐González, María José Ruiz‐López, Zulima Tablado, Elena Tena, Estefanía Tobajas, Elena Velado‐Alonso, Pablo Villalva, Nacho Villar, Marcello D'Amico   +23 more
wiley   +1 more source

Measurement of jet quenching with I_CP and I_AA,Pythia in Pb-Pb collisions at sqrt(s_NN) = 2.76 TeV with ALICE

, 2011
This paper discusses the measurement of I_CP and I_AA,Pythia with ALICE (A Large Ion Collider Experiment). An away-side suppression is found expected from in-medium energy loss.
Grosse-Oetringhaus, Jan Fiete
core  

Improved prediction of symptomatic type 1 diabetes using a luciferase‐based assay to measure (pro)insulin autoantibodies

Diabetic Medicine, EarlyView.
Abstract Introduction Insulin autoantibodies (IAA) are key predictors of type 1 diabetes, particularly in young children. Micro‐radiobinding assays (RBA) are the gold standard for IAA measurement but have limitations. We assessed whether a luciferase immunoprecipitation system (LIPS) assay improved diabetes risk assessment.
Rebecca C. Wyatt, Cristina Brigatti, Sian L. Grace, Claire L. Williams, Ilaria Marzinotto, Ben T. Gillard, Elena Bazzigaluppi, Deborah Shoemark, Michela A.‐M. Chandler, Peter Achenbach, Lorenzo Piemonti, BOX Study Group, Isabel Wilson, Rachel Aitken, Ilana Kelland, Clare Megson, Chitrabhanu Ballav, Atanu Dutta, Michelle Russell‐Taylor, Rachel Besser, James Bursell, Shanthi Chandran, Sejal Patel, Anne Smith, Manohara Kenchaiah, Gomathi Margabanthu, Foteini Kavvoura, Chandan Yaliwal, AWAF, Rachel Aitken, Olivia Pearce, Sarah Stollery, Elinor Balch, Hanah Batholomew, Zhara Hashmi, Kathleen M. Gillespie, Vito Lampasona, Alistair J. K. Williams, Anna E. Long   +38 more
wiley   +1 more source

Advancing Early‐Stage Type 1 Diabetes Care: Future Focused Pathways for Identification, Screening, Diagnosis, and Monitoring

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Although international guidelines provide recommendations for screening and monitoring of early‐stage type 1 diabetes (T1D), navigating the care pathway can still be difficult for individuals, caregivers, and healthcare professionals (HCPs). These challenges are exacerbated by variations in healthcare systems, gaps in communication,
Chantal Mathieu, Valentino Cherubini, Thomas Kapellen, Noemí González Pérez de Villar, Guendalina Graffigna, Alix Besancon, Alfred Penfornis, Justin Gregory, Monica Bertolini, Maria Asunción Martinez‐Brocca, Korey Hood, Tabitha Randell, Ralph Ziegler, Parth Narendran, Carla Demeterco‐Berggren   +14 more
wiley   +1 more source

Islet Autoantibodies in Adult With Pituitary and Ovarian Autoimmunity: Implications for Type 1 Diabetes Screening

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Purpose Type 1 diabetes is a chronic autoimmune disease characterised by progressive pancreatic β‐cell destruction and the early appearance of islet autoantibodies (islet‐AAb) during the pre‐symptomatic phases. Given the growing interest in screening and prevention of type 1 diabetes, this study aimed to assess the prevalence of pancreatic ...
Giuseppe Bellastella, Michela di Nuzzo, Miriam Longo, Paolo Cirillo, Antonietta Maio, Nicole Di Martino, Silvia Angelino, Paola Caruso, Lorenzo Scappaticcio, Maria Teresa Vietri, Maria Ida Maiorino, Katherine Esposito   +11 more
wiley   +1 more source