Results 121 to 130 of about 55,645 (264)

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, EarlyView.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

Indole-3-acetic acid production is rare among gut bacteria and reflects OFOR-driven amino acid oxidation in acetogens. [PDF]

Gut Microbes
DeFeo ME, Liu Y, Zhou Z, Higginbottom SK, Dodd D.   +4 more
europepmc   +1 more source

Economic Power of Political Leaders: Evidence From Central Leaders' Local Tours in China

The Developing Economies, EarlyView.
ABSTRACT Do political leaders play a role in shaping economic outcomes? Can we quantify and compare the economic influence of contemporary political leaders? This paper examines the economic impact of autocratic leadership through the lens of firm visits in China, offering a unique empirical strategy to assess their influence.
Asei Ito, Jaehwan Lim, Hongyong Zhang
wiley   +1 more source

Genome-wide unraveling of the <i>AUX/IAA</i> family in <i>Avena sativa</i> L. with observations on seedling root growth and stress resilience. [PDF]

Front Plant Sci
Li Q, Wang Y, Liu F, Yuan S, Yuan Y, Bai M, Zhao Z, Zhou Q, Chen C, Chen Y.   +9 more
europepmc   +1 more source

Understanding parents' perspectives of repeated blinded continuous glucose monitoring in children with early‐stage type 1 diabetes and an affected first‐degree relative

Diabetic Medicine, EarlyView.
Abstract Aim To explore the lived experiences of parents of children at risk of type 1 diabetes (T1D) undergoing repeated blinded continuous glucose monitoring (CGM). Method Since 2021, children with persistent islet autoimmunity in the Environmental Determinants of Islet Autoimmunity (ENDIA) study have been invited to participate in a sub‐study ...
Alexandra S. Tully, Sabrina K. Binkowski, Brydie‐Rose Nevin, Megan A. S. Penno, Amanda J. Anderson, Maria E. Craig, Peter G. Colman, Tony Huynh, Kelly J. McGorm, Georgia Soldatos, John M. Wentworth, Elizabeth A. Davis, Jenny J. Couper, Keely R. Bebbington, Aveni Haynes, on behalf of the ENDIA Study Group   +15 more
wiley   +1 more source

Long‐Term Follow‐Up Incidence of Type 1 Diabetes and Associated Autoimmune Diseases in First‐Degree Relatives

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background First‐degree relatives (FDRs) of individuals with type 1 diabetes (T1D) carry a significantly elevated risk of developing autoimmune diseases, including celiac disease (CD) and autoimmune thyroid disease (AITD). The DiaUnion 1.0 study aimed to characterize one‐time autoantibodies, genetic risk profiles and long‐term progression to ...
Julie H. Christensen, Gitte Lindved Petersen, Simranjeet Kaur, Alexander Lind, Samia Hamdan, Maria Naredi Scherman, Jesper Johannesen, Daniel Agardh, Julie C. Antvorskov, Flemming Pociot   +9 more
wiley   +1 more source

A "One-Stone-Three-Birds" Inspired Nanoplatform for Multitargeted Ulcerative Colitis Therapy via Combined Aryl Hydrocarbon Receptor Activation and Reactive Oxygen Species Scavenging. [PDF]

Biomater Res
Dong K, Guan Z, Wang D, Sun J, Zhang Y, You C, Xing Y.   +6 more
europepmc   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Indole-3-Acetic Acid Biosynthesis by Endophytic Fungi and Its Association with Plant-Fungus Interactions. [PDF]

J Fungi (Basel)
Turbat A, Vigneshwari A, Huynh T, Oyunbat N, Tiwari A, Ramteke PW, Varga M, Papp T, Vágvölgyi C, Szekeres A.   +9 more
europepmc   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source