Results 61 to 70 of about 34,906 (267)

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

open access: yesAdvanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun   +14 more
wiley   +1 more source

Genotoxicity and Safety Pharmacology Studies of Indole Alkaloids Extract from Leaves of Alstonia scholaris (L.) R. Br.

open access: yesNatural Products and Bioprospecting, 2020
Indole alkaloids extract (IAAS) was prepared from leaves of Alstonia scholaris (L.) R. Br., an evergreen tropical plant widely distributed throughout the world.
Yun-Li Zhao   +9 more
doaj   +1 more source

Cloud-based solutions used by hungarian SMEs and analysis of its effects

open access: yesActa Academiae Beregsasiensis. Economics, 2023
The wide range of technological innovations took place in the post-millennium period and later became widely available have fundamentally reshaped the relationship between ICT infrastructure and business in the life of for-profit organizations.
Adam Bela Horvath
doaj   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang   +18 more
wiley   +1 more source

Effect of stocking density and source of animal protein on growth and survival of rainbow trout fingerlings in flow-through system at Nuwakot, Nepal

open access: yesAquaculture Reports, 2017
An experiment was conducted in outdoor nursing raceways with flow-through system (2.7 m2) at the Fisheries Research Station, Trishuli, Nuwakot Nepal for 249 days to evaluate the effect of stocking density and sources of animal protein on growth and ...
Prem Timalsina   +4 more
doaj   +1 more source

Securely Launching Virtual Machines on Trustworthy Platforms in a Public Cloud [PDF]

open access: yes, 2012
In this paper we consider the Infrastructure-as-a-Service (IaaS) cloud model which allows cloud users to run their own virtual machines (VMs) on available cloud computing resources.
Aslam, Mudassar   +3 more
core   +1 more source

An Ontology based System for Cloud Infrastructure Services Discovery

open access: yes, 2012
The Cloud infrastructure services landscape advances steadily leaving users in the agony of choice. As a result, Cloud service identification and discovery remains a hard problem due to different service descriptions, non standardised naming conventions ...
Georgakopoulos, Dimitrios   +5 more
core   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang   +16 more
wiley   +1 more source

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

open access: yesAdvanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao   +14 more
wiley   +1 more source

Safeguarding rice crops in Nepal: unveiling strategies against the yellow stem borer (Scirpophaga incertulas)

open access: yesDiscover Agriculture
Rice (Oryza sativa L.) is a vital crop with enormous economic and nutritional importance in Nepal and worldwide. The yellow stem borer (YSB), Scirpophaga incertulas (Walker) (Lepidoptera: Crambidae), is a monophagous severe pest that poses a substantial ...
Susmita Subedi   +3 more
doaj   +1 more source

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