Results 61 to 70 of about 3,544 (263)
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Heat stress and it’s tolerance in wheat
Cogent Food & AgricultureThe rise in world temperature has led to remarkable changes in global climate patterns, eventually devastating the crops. Climate change has led to the emergence of various abiotic factors which has decreased the crop’s productivity.
Sashi Bhusan Kumar Yadav, Suchi Bhatt
doaj +1 more source
INTEGRATED NUTRIENT MANAGEMENT ON HYBRID MAIZE (ZEA MAYS L.) PRODUCTION IN LAMAHI DANG, NEPAL [PDF]
Big Data in AgricultureThe key to sustainable agricultural production and environmental protection is the prudent use of both organic and inorganic fertilizers. With these goals in mind, an experiment was carried out in the spring of 2021 in Lamahi municipality Dang district ...
Prabesh Pandit +2 more
doaj +1 more source
Advanced Science, EarlyView.Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui +7 more
wiley +1 more source
A Universal Protein Ladder for Standardization of Diverse FRET Assays
Advanced Science, EarlyView.Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith +5 more
wiley +1 more source
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 A process based on the role approach for the synthesis of information security models of cloud computing systems based on applied system and threat models is described; the result is a security model, expressed, for example, in recommendations for ...
E. V. Olizarovich, A. I. Brazhuk
doaj +1 more source
IaaS Service Selection Revisited
, 2018 Cloud computing is a paradigm that has revolutionized the way service-based applications are developed and provisioned due to the main benefits that it introduces, including more flexible pricing and resource management. The most widely used kind of cloud service is the Infrastructure-as-a-Service (IaaS) one.
Kyriakos Kritikos, Geir Horn
openaire +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source