Results 61 to 70 of about 194,646 (276)

Layered evaluation of interactive adaptive systems : framework and formative methods [PDF]

, 2010
Peer ...
Masthoff, Judith, Paramythis, Alexandros, Weibelzahl, Stephan   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prudence vs. Credibility. A Formal Comparative Analysis between Romanian Accounting Regulations and IFRS

Audit Financiar, 2019
Starting from the controversial influence that prudence may have on the credibility of accounting information and from the fact that there are different views of the global accounting systems on this concept, the present research aims to analyze the ...
doaj   +1 more source

Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm

Journal of Translational Medicine, 2020
Background Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptured IAs and trained machine ...
Kerry E. Poppenberg, Vincent M. Tutino, Lu Li, Muhammad Waqas, Armond June, Lee Chaves, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Hui Meng   +13 more
doaj   +1 more source

Beta-decay properties of $^{25}$Si and $^{26}$P [PDF]

, 2004
The $\beta$-decay properties of the neutron-deficient nuclei $^{25}$Si and $^{26}$P have been investigated at the GANIL/LISE3 facility by means of charged-particle and $\gamma$-ray spectroscopy.
A. Ensallem, A. Jokinen, A. Laird, Anderson, Antony, Audi, Axelsson, B. Blank, Barker, Barton, Brown, C. Longour, Cable, Cable, Canchel, Chou, Endt, Endt, F. de Oliveira Santos, G. Canchel, Hatori, J. Giovinazzo, J. Honkanen, J. Äystö, J.-C. Thomas, K. Peräjärvi, Kubodera, L. Achouri, M. Lewitowicz, M. Stanoiu, Muto, N. Guillet, P. Dendooven, R. Béraud, Reeder, Robertson, S. Czajkowski, Sextro, Smirnova, Tilley, Tilley, Tilley, Towner, Towner, Wildenthal, Wildenthal, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Zhou   +50 more
core   +6 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Value Relevance of Control-based Consolidated Financial Statements [PDF]

, 2015
The study examines whether the switch from ownership-based guidelines for control under SSAP-8 to the principles-based guidelines (power and benefits) of FRS-37 increased the value relevance of consolidated financial statements in New Zealand.
Barcham, R, Bradbury, M
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Prevalence of metabolic syndrome in Brazilian adults in the last 10 years: a systematic review and meta-analysis

BMC Public Health, 2022
Background A cluster of interconnected cardiometabolic risk factors characterizes metabolic Syndrome (MS). The prevalence of MS is increasing worldwide, but there is not a meta-analysis of this prevalence in the Brazilian population.
Letícia Teixeira de Siqueira Valadares, Luiza Siqueira Barreto de Souza, Valdir Alves Salgado Júnior, Larissa de Freitas Bonomo, Leandro Roberto de Macedo, Maísa Silva   +5 more
doaj   +1 more source

Recurrent Attention Models for Depth-Based Person Identification [PDF]

, 2016
We present an attention-based model that reasons on human body shape and motion dynamics to identify individuals in the absence of RGB information, hence in the dark.
Alahi, Alexandre, Fei-Fei, Li, Haque, Albert   +2 more
core   +2 more sources