Results 21 to 30 of about 390,111 (338)

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.

Cell, 2020
Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a personalized neoantigen-based vaccine, NEO-PV-01, in combination with PD-
P. Ott, S. Hu-Lieskovan, B. Chmielowski, R. Govindan, A. Naing, N. Bhardwaj, K. Margolin, M. Awad, M. Hellmann, Jessica J. Lin, T. Friedlander, M. Bushway, Kristen N. Balogh, Tracey E. Sciuto, Victoria L. Kohler, S. Turnbull, Rana H. Besada, Riley R. Curran, Benjamin Trapp, J. Scherer, A. Poran, D. Harjanto, D. Barthelme, Ying S. Ting, Jesse Z. Dong, Yvonne Ware, Yuting Huang, Zhengping Huang, Amy Wanamaker, Lisa D. Cleary, M. A. Moles, K. Manson, J. Greshock, Z. Khondker, E. Fritsch, Michael S. Rooney, M. DeMario, R. Gaynor, L. Srinivasan   +38 more
semanticscholar   +1 more source

Sucrose-phosphate phosphatase from sugarcane reveals an ancestral tandem duplication

BMC Plant Biology, 2021
Background Sugarcane is capable to store large amounts of sucrose in the culm at maturity hence it became a major source of sucrose for the food and the renewable energy industries.
Vania Gabriela Sedano Partida, Henrique Moura Dias, Diana Susana Martinez Corcino, Marie-Anne Van Sluys   +3 more
doaj   +1 more source

Phase IB/II Trial of Lenvatinib Plus Pembrolizumab in Patients With Advanced Renal Cell Carcinoma, Endometrial Cancer, and Other Selected Advanced Solid Tumors

Journal of Clinical Oncology, 2020
PURPOSE Modulation of vascular endothelial growth factor–mediated immune suppression via angiogenesis inhibition may augment the activity of immune checkpoint inhibitors.
Matthew H. Taylor, Chung-Han Lee, V. Makker, D. Rasco, C. Dutcus, Jane Wu, D. Stepan, R. Shumaker, R. Motzer   +8 more
semanticscholar   +1 more source

Concurrent occurrence of infectious bursal disease and respiratory complex caused by infectious bronchitis and avian influenza (H9N2) in broilers

Bulgarian Journal of Veterinary Medicine, 2022
Infectious bursal disease (IBD) virus is considered one of the commonest immunosuppressive dis-eases in chickens. The aim of this study was to investigate the concurrent occurrence of subclinical IBD in respiratory complex infections caused by avian ...
J. Taifebagherlu, A. Talebi, M. Allymehr
doaj   +1 more source

IB-homogeneous graphs

Discrete Mathematics, 2022
The Lachlan-Woodrow Theorem identifies ultrahomogeneous graphs up to isomorphism. Recently, the present author and D. Hartman classified MB-homogeneous graphs up to bimorphism-equivalence. We extend those results in this paper, showing that every IB-homogeneous graph is either ultrahomogeneous or MB-homogeneous, and thus all the IB-homogeneous graphs ...
openaire   +2 more sources

Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial

Journal for ImmunoTherapy of Cancer, 2020
Background Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. As tumor
J. Martín-Broto, N. Hindi, G. Grignani, J. Martínez-Trufero, A. Redondo, C. Valverde, S. Stacchiotti, A. López-Pousa, L. D’Ambrosio, A. Gutiérrez, H. Pérez-Vega, Victor Encinas-Tobajas, E. de Álava, P. Collini, M. Peña-Chilet, J. Dopazo, I. Carrasco-Garcia, M. López-Álvarez, D. Moura, J. López-Martín   +19 more
semanticscholar   +1 more source

IB Index: Developing a Standard Evaluation System for Intelligent Buildings [PDF]

, 2022
Thesis (Ph.D.)--University of Washington, 2022Intelligent building is a rapidly growing market in the Architecture, Engineering, Construction, and Operation (AECO) industry that aims to deploy emerging technologies and leverage data-driven decision ...
Borhani, Seyed Alireza
core   +1 more source

Ensinar por meio da Pedagogia por Projetos: reflexões acerca da prática de uma professora iniciante

Revista de Iniciação à Docência, 2021
O artigo apresenta a análise de uma professora iniciante de carreira sobre a própria prática ao adequar suas ações pedagógicas à perspectiva da concepção de ensino pela Pedagogia por Projetos de Josette Jolibert no decorrer de uma investigação ...
Daiane Luzia de Matos Bueno, Fabiana Rosa Vilela de Oliveira Guilherme   +1 more
doaj   +1 more source

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Nature, 2018
Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt from central tolerance, can generate robust immune responses1,2 and can function as bona fide antigens that facilitate tumour rejection3.
D. Keskin, Annabelle J Anandappa, Jing Sun, I. Tirosh, N. Mathewson, Shuqiang Li, G. Oliveira, A. Giobbie-Hurder, K. Felt, E. Gjini, S. Shukla, Zhuting Hu, Letitia W. Li, Phuong M. Le, R. Allesøe, Alyssa R. Richman, Monika S. Kowalczyk, Sara Abdelrahman, Jack Geduldig, Sarah K Charbonneau, K. Pelton, J. Iorgulescu, Liudmila Elagina, Wandi Zhang, Oriol Olive, Christine McCluskey, L. Olsen, Jonathan D. Stevens, W. Lane, A. Salazar, H. Daley, P. Wen, E. Chiocca, M. Harden, N. Lennon, S. Gabriel, G. Getz, E. Lander, A. Regev, J. Ritz, D. Neuberg, S. Rodig, K. Ligon, M. Suvà, K. Wucherpfennig, N. Hacohen, E. Fritsch, K. Livak, P. Ott, Catherine J. Wu, D. Reardon   +50 more
semanticscholar   +1 more source

Phase IA/IB study of single-agent tislelizumab, an investigational anti-PD-1 antibody, in solid tumors

Journal for ImmunoTherapy of Cancer, 2020
Background The programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) axis plays a central role in suppressing antitumor immunity; axis dysregulation can be used by cancer cells to evade the immune system.
J. Desai, S. Deva, J. Lee, Chia‐Chi Lin, C. Yen, Y. Chao, B. Keam, M. Jameson, M. Hou, Yoon-Koo Kang, B. Markman, C. Lu, K. Rau, Kyung-Hun Lee, L. Horvath, M. Friedlander, A. Hill, S. Sandhu, P. Barlow, Chi‐Yuan Wu, Yun Zhang, Liang Liang, John Wu, V. Paton, M. Millward   +24 more
semanticscholar   +1 more source