Results 171 to 180 of about 630,918 (284)

What Is Your Diagnosis? Multiple Subcutaneous Lumps in a Horse

open access: yes
Veterinary Clinical Pathology, EarlyView.
Federica Meistro   +4 more
wiley   +1 more source

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1288-1297, May 2026.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard   +4 more
wiley   +1 more source

Surface Plasmon Resonance (SPR) Workflow for Comparative Analysis of Nanobody Variants Binding to Lysozyme as a Model Ligand

open access: yesCurrent Protocols, Volume 6, Issue 5, May 2026.
Abstract Developing protein interaction–based technologies such as biosensors requires a clear understanding of receptor‐target kinetics. Nanobodies, which are camelid‐derived single‐domain antibodies, are ideal biosensor receptors due to their high specificity, stability, and ease of production. During biosensor development, multiple nanobody variants
Escarlet Díaz‐Galicia   +5 more
wiley   +1 more source

Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation

open access: yesClinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• The activation of the microglial Hcar2 receptor by niacin initiates intracellular signalling that induces metabolic reprogramming. • This metabolic shift is characterized by increased oxidative phosphorylation. Consequently, microglia polarize from a proinflammatory state toward an anti‐inflammatory, reparative phenotype.
Hua Du   +7 more
wiley   +1 more source

Performance Benchmarking of Optimized Stacked Ensemble Frameworks in Blood Glucose Level (BGL) Prediction

open access: yesEngineering Reports, Volume 8, Issue 5, May 2026.
Optimized stacked ensemble framework for precise Blood Glucose Level (BGL) prediction, demonstrating improved accuracy and reliability through integrated machine learning models. ABSTRACT This paper presents a study of different stacked ensemble techniques for long‐term Blood Glucose Level (BGL) prediction in adults.
Ashwani Kharola   +8 more
wiley   +1 more source

Microglial Inhibition Promotes Proliferation and Differentiation of Neural Stem Cells via STAT3/SDF‐1/CXCR4 Signaling Pathway in Hypoxic–Ischemic Encephalopathy

open access: yesGlia, Volume 74, Issue 5, May 2026.
Partial microglial depletion indirectly promoted the activity of the STAT3 signaling pathway in neural cells and increased the proliferation and/or differentiation of NSCs in areas of infarction to exert neuroprotective effects via the paracrine effects of NSCs and immature neurons in HIE.
Ao Ding   +10 more
wiley   +1 more source

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