The authors report the development of a controlled and scalable 3D co‐culture system combining hiPSC‐derived erythromyeloid progenitors and neurospheres within the Ambr® 250 Modular platform operated with a newly designed perfusion system. This model faithfully recapitulates early microglia–neural interactions, enabling progenitor integration ...
Catarina M. Gomes +4 more
wiley +1 more source
<i>Meta</i>-Topolin as an Aromatic Cytokinin for <i>In Vitro</i> Propagation of <i>Thymus vulgaris</i> L. [PDF]
Mabotja MB +4 more
europepmc +1 more source
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu +6 more
wiley +1 more source
Indole-3-Butyric Acid (IBA) Derivatives for Root Architecture Modulation: Potent Promoters via <i>In Vivo</i> Conversion to IBA and Selective Inhibitors for Lateral Root Formation. [PDF]
Kikuchi R +7 more
europepmc +1 more source
Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins
Random hetero oligomers (RHOs) of defined compositions are synthesized and fractionated to identify the chemical design criteria (charge, length, hydrophobicity) required to achieve nanomolar binding to green fluorescent protein, resulting in >100% fluorescence increases.
Darwin C. Gomez +12 more
wiley +2 more sources
PPAR-γ activation by pioglitazone inhibits microglia-mediated neuroinflammation and alleviates disease in neuromyelitis optica spectrum disorders. [PDF]
Yick LW +6 more
europepmc +1 more source
Targeting the Spinal Cord-Brain Axis: Electroacupuncture Mitigates Remote Frontal Cortex Neuroinflammation via HMGB1/TLR4 to Aid Functional Recovery After Spinal Cord Injury. [PDF]
Spinal cord injury (SCI) has been shown to trigger remote neuroinflammation in the frontal cortex via the HMGB1/TLR4/NF‐κB pathway, exacerbating neural damage and impairing functional recovery. The present study demonstrates that electroacupuncture (EA) at GV4 (Mingmen) and GV14 (Dazhui) effectively mitigates this pathological cascade.
Ning Y +9 more
europepmc +2 more sources
Treadmill training protects against white matter injury and reduces cerebral infarction. Muscle‐derived mitochondrial transfer via platelets is promoted by treadmill training. Platelet transfusion emerges as a potential low‐risk therapeutic strategy for sequelae and vascular dementia.
Toshiki Inaba +8 more
wiley +1 more source
Differential benefits of internet-based behavioral activation (iBA) for adolescents with high vs. low reward probability: a secondary analysis. [PDF]
Kim YS, Lee E, Choi KH.
europepmc +1 more source

