Results 231 to 240 of about 664,384 (364)

Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 2, Page 363-378, February 2026.
The authors report the development of a controlled and scalable 3D co‐culture system combining hiPSC‐derived erythromyeloid progenitors and neurospheres within the Ambr® 250 Modular platform operated with a newly designed perfusion system. This model faithfully recapitulates early microglia–neural interactions, enabling progenitor integration ...
Catarina M. Gomes   +4 more
wiley   +1 more source

The ZNF148‐ZEB1‐AS1‐IGF2BP2‐NOD2 Axis Drives Microglial Antipneumococcal Immunity in Bacterial Meningitis

open access: yesGlia, Volume 74, Issue 2, February 2026.
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu   +6 more
wiley   +1 more source

Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins

open access: yesAngewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Random hetero oligomers (RHOs) of defined compositions are synthesized and fractionated to identify the chemical design criteria (charge, length, hydrophobicity) required to achieve nanomolar binding to green fluorescent protein, resulting in >100% fluorescence increases.
Darwin C. Gomez   +12 more
wiley   +2 more sources

Targeting the Spinal Cord-Brain Axis: Electroacupuncture Mitigates Remote Frontal Cortex Neuroinflammation via HMGB1/TLR4 to Aid Functional Recovery After Spinal Cord Injury. [PDF]

open access: yesBrain Behav
Spinal cord injury (SCI) has been shown to trigger remote neuroinflammation in the frontal cortex via the HMGB1/TLR4/NF‐κB pathway, exacerbating neural damage and impairing functional recovery. The present study demonstrates that electroacupuncture (EA) at GV4 (Mingmen) and GV14 (Dazhui) effectively mitigates this pathological cascade.
Ning Y   +9 more
europepmc   +2 more sources

Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro‐Glial Protection Against Cerebral Ischemia

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Treadmill training protects against white matter injury and reduces cerebral infarction. Muscle‐derived mitochondrial transfer via platelets is promoted by treadmill training. Platelet transfusion emerges as a potential low‐risk therapeutic strategy for sequelae and vascular dementia.
Toshiki Inaba   +8 more
wiley   +1 more source

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