Results 21 to 30 of about 2,130 (186)
Molecular Autism, 2021 Background Autism spectrum disorders (ASD) are synaptopathies characterized by area-specific synaptic alterations and neuroinflammation. Structural and adhesive features of hippocampal synapses have been described in the valproic acid (VPA) model ...
Marianela Evelyn Traetta +5 more
doaj +1 more source
Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration
Frontiers in Pharmacology, 2022 Continuous illumination induces the degeneration of photoreceptors. This animal model of light-induced retinal degeneration resembles many characteristics of human degenerative diseases of the outer retina, such as age-related macular degeneration.
Manuel Soliño +8 more
doaj +1 more source
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice
British Journal of Pharmacology, Volume 179, Issue 8, Page 1732-1752, April 2022., 2022 Background and Purpose Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. Although considered to be a pure motor neuron disease, increasing evidence indicates that the sole protection of ...
Silvia Scaricamazza +25 more
wiley +1 more source
Ghent University-IBCN participation in the TAC KBP 2015 cold start slot filling task [PDF]
, 2015 Deleu, Johannes +3 more
core +3 more sources
Frontiers in Aging Neuroscience, 2021 Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media.
Martín Habif +14 more
doaj +1 more source
MiR‐142‐3p regulates synaptopathy‐driven disease progression in multiple sclerosis
Neuropathology and Applied Neurobiology, Volume 48, Issue 2, February 2022., 2022 By combining clinical and preclinical studies, De Vito et al. propose miR‐142‐3p to be a potential synaptotoxic and negative prognostic marker in multiple sclerosis. Keeping miR‐142‐3p at a low‐level through a personalised therapy may be a promising strategy to improve the disease course in multiple sclerosis.
Francesca De Vito +30 more
wiley +1 more source
Disease Markers, Volume 2022, Issue 1, 2022., 2022 Background. Thioesterase superfamily member 6 (THEM6) has been implicated in the development and progression of various cancers. However, prior research emphasized on its regulatory role merely, we aim to investigate the effect of THEM6 gene on the immunological role and its relationship with molecular subtype in bladder cancer (BLCA). Methods. Through
Xu Zhao +9 more
wiley +1 more source
Molecular Plant Pathology, Volume 22, Issue 12, Page 1599-1612, December 2021., 2021 Cloning of avirulence gene AvrLm14 in Leptosphaeria maculans allowed us to identify the first resistance gene to the fungus in Brassica oleracea; therefore B. oleracea diversity may be exploited to find novel resistance to the disease. Abstract In many cultivated crops, sources of resistance to diseases are sparse and rely on introgression from wild ...
Alexandre Degrave +10 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2020 Perinatal ethanol (EtOH) exposure is associated with high incidence of behavioral disorders such as depression and anxiety. The cerebral areas related with these consequences involve the corticolimbic system, in particular the prefrontal cortex ...
Catalina Madarnas +5 more
doaj +1 more source
Frontiers in Neuroscience, 2021 N-methyl-D-aspartate receptors are heterotetramers composed of two GluN1 obligatory subunits and two regulatory subunits. In cognitive-related brain structures, GluN2A and GluN2B are the most abundant regulatory subunits, and their expression is ...
Maria Florencia Acutain +10 more
doaj +1 more source