Results 221 to 230 of about 145,684 (315)

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong   +7 more
wiley   +1 more source

Circulant Matrix‐Based Box–Behnken Designs With Economic Run Sizes

open access: yesQuality and Reliability Engineering International, EarlyView.
ABSTRACT We introduce Circulant Matrix‐Based Box–Behnken Designs (CBBDs), a new class of three‐level, second‐order response surface designs constructed using circulant matrix structures. These designs satisfy an enhanced orthogonal minimally aliased (OMA∗${\rm OMA}^*$) property: they retain the classical OMA property—where main effects are orthogonal ...
Tung‐Dinh Pham, Nam‐Ky Nguyen
wiley   +1 more source

Deep‐Learning Algorithm Diagnostic Support for Usual Interstitial Pneumonia Pattern Recognition in Fibrotic Interstitial Lung Disease

open access: yesRespirology, EarlyView.
ABSTRACT Background and Objective High resolution computed tomography (HRCT) scan diagnostic classification for usual interstitial pneumonia (UIP) plays a critical role in therapeutic decision‐making and clinical trial eligibility for interstitial lung disease (ILD) patients, but is subject to variability.
Caitlin C. Fermoyle   +313 more
wiley   +1 more source

Editorial: Host-microbiota interactions in IBD: immune modulation and barrier function. [PDF]

open access: yesFront Cell Infect Microbiol
Li H   +3 more
europepmc   +1 more source

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

open access: yesSmall, EarlyView.
This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang   +16 more
wiley   +1 more source

Model‐Based Systems Engineering in Space Applications: A Comprehensive Literature Review

open access: yesSystems Engineering, EarlyView.
ABSTRACT The growing complexity of space engineering is driving the demand to embrace the adoption of Model‐Based Systems Engineering (MBSE). Although the MBSE is well‐practiced in the space industry, the level of effort and need required to obtain the benefits of MBSE vastly differ across enterprises; this disparity presents a significant challenge to
Rehobot Bekele Buruso   +4 more
wiley   +1 more source

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