Results 41 to 50 of about 2,088 (198)

Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off-target effect of radiotherapy. [PDF]

Cell Prolif
Radiotherapy‐induced effects, especially in whole brain irradiation, involve both tumour and surrounding healthy cells. Irradiated tumour and microglia cells create a complex network of intercellular communication. Our data reveal that off‐target irradiated microglia increase GBM viability, proliferation and growth, sustaining GBM mitochondrial fitness.
Alberghina C, Torrisi F, D'Aprile S, Longhitano L, Giallongo S, Scandura G, Mannino G, Mele S, Sabini MG, Cammarata FP, Russo G, Abdelhameed AS, Zappalà A, Lo Furno D, Giuffrida R, Li Volti G, Tibullo D, Vicario N, Parenti R.   +18 more
europepmc   +2 more sources

In silico identification of drug target pathways in breast cancer subtypes using pathway cross-talk inhibition

Journal of Translational Medicine, 2018
Background Despite great development in genome and proteome high-throughput methods, treatment failure is a critical point in the management of most solid cancers, including breast cancer (BC).
Claudia Cava, Gloria Bertoli, Isabella Castiglioni   +2 more
doaj   +1 more source

Quantum phase transitions in the interacting boson model [PDF]

, 2008
This review is focused on various properties of quantum phase transitions (QPTs) in the Interacting Boson Model (IBM) of nuclear structure. The model in its infinite-size limit exhibits shape-phase transitions between spherical, deformed prolate, and ...
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core   +1 more source

Biomarkers of Eating Disorders Using Support Vector Machine Analysis of Structural Neuroimaging Data: Preliminary Results

Behavioural Neurology, 2015
Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization ...
Antonio Cerasa, Isabella Castiglioni, Christian Salvatore, Angela Funaro, Iolanda Martino, Stefania Alfano, Giulia Donzuso, Paolo Perrotta, Maria Cecilia Gioia, Maria Carla Gilardi, Aldo Quattrone   +10 more
doaj   +1 more source

Amyotrophic Lateral Sclerosis: A Diet Review

Foods, 2021
Amyotrophic lateral sclerosis (ALS) is a fatal disease related to upper and lower motor neurons degeneration. Although the environmental and genetic causes of this disease are still unclear, some factors involved in ALS onset such as oxidative stress may
Salvatore D’Antona, Martina Caramenti, Danilo Porro, Isabella Castiglioni, Claudia Cava   +4 more
doaj   +1 more source

MRI Characterizes the Progressive Course of AD and Predicts Conversion to Alzheimer’s Dementia 24 Months Before Probable Diagnosis

Frontiers in Aging Neuroscience, 2018
There is no disease-modifying treatment currently available for AD, one of the more impacting neurodegenerative diseases affecting more than 47.5 million people worldwide.
Christian Salvatore, Antonio Cerasa, Isabella Castiglioni   +2 more
doaj   +1 more source

Exoskeleton-Robot Assisted Therapy in Stroke Patients: A Lesion Mapping Study

Frontiers in Neuroinformatics, 2018
Background: Technology-supported rehabilitation is emerging as a solution to support therapists in providing a high-intensity, repetitive and task-specific treatment, aimed at improving stroke recovery.
Antonio Cerasa, Antonio Cerasa, Loris Pignolo, Vera Gramigna, Sebastiano Serra, Giuseppe Olivadese, Federico Rocca, Paolo Perrotta, Giuliano Dolce, Aldo Quattrone, Aldo Quattrone, Paolo Tonin   +11 more
doaj   +1 more source

Quantum phase transitions in odd-A nuclei: The effect of the odd particle from spherical to oblate shapes [PDF]

, 2015
Quantum shape-phase transitions in odd-nuclei are investigated within the framework of the interacting boson-fermion model (IBFM). We consider the case of a single-j fermion coupled to an even-even boson core that performs a transition from spherical to ...
Alonso Alonso, Clara Eugenia, Arias Carrasco, José Miguel, Böyükata, Mahmut, Fortunato, Lorenzo, Vitturi, Andrea   +4 more
core   +2 more sources

A protein interaction map identifies existing drugs targeting SARS-CoV-2

BMC Pharmacology and Toxicology, 2020
Background Severe acute respiratory syndrome coronavirus (SARS-CoV-2), an emerging Betacoronavirus, is the causative agent of COVID-19. Angiotensin converting enzyme 2 (ACE2), being the main cell receptor of SARS-CoV-2, plays a role in the entry of the ...
Claudia Cava, Gloria Bertoli, Isabella Castiglioni   +2 more
doaj   +1 more source

Shape-phase transitions in odd-mass $\gamma$-soft nuclei with mass $A\approx 130$

, 2017
Quantum phase transitions between competing equilibrium shapes of nuclei with an odd number of nucleons are explored using a microscopic framework of nuclear energy density functionals and a particle-boson core coupling model.
Nikšić, T., Nomura, K., Vretenar, D.
core   +1 more source