Results 61 to 70 of about 20,438 (241)

The impact of inflammatory burden index on the prognosis in acute decompensated heart failure: evidence from a cohort study in Jiangxi, China

Frontiers in Cardiovascular Medicine
ObjectiveAcute decompensated heart failure (ADHF) is the most common and severe type of HF. The aim of this study is to evaluate the impact and predictive value of a novel inflammatory marker, the inflammatory burden index (IBI), on the 30-day mortality ...
Kun Jiang, Kun Jiang, Kun Jiang, Guoan Jian, Guoan Jian, Guoan Jian, Zihao Lu, Zihao Lu, Zihao Lu, Shiming He, Shiming He, Shiming He, Xinfang Huang, Lin Xie, Shuhua Zhang, Qun Wang, Hengcheng Lu, Zhiyu Xiong, Zhiting Wu, Guotai Sheng, Yang Zou, Aimin Xie, Hengli Lai, Wei Wang   +23 more
doaj   +1 more source

Development and Validation of the Individual Burden of Illness Index for Major Depressive Disorder (IBI-D)

Administration and Policy in Mental Health and Mental Health Services Research, 2013
This study aims at developing a single numerical measure that represents a depressed patient’s individual burden of illness. An exploratory study examined depressed outpatients (n = 317) followed by a hypothesis confirmatory study using the NIMH STAR*D ...
W. Ishak, Jared Greenberg, Tammy Saah, S. Mobaraki, Hala Fakhry, Qian Wu, E. Ngor, Fei Yu, R. Cohen   +8 more
semanticscholar   +1 more source

“White and Clear” (WaC): A tunable hydrophilic tissue clearing strategy for multi‐species 3D imaging

VIEW, EarlyView.
Optical tissue clearing methods help scientists make tissues transparent to image structures deep inside organs in 3D, but many existing techniques are limited in performance and difficulty. In this study, we developed an optimized clearing method called WaC (White and Clear), which improves upon existing techniques by combining efficient tissue ...
Vicente Llorente, Elena Fernández‐Cortés, Daniel Sanderson, Julia Carolina Salazar Romero, Juan Miguel Gil‐Jaurena, Esther Bernaldo‐de‐Quirós, Rafael J. Jiménez‐Riobóo, Rafael Correa‐Rocha, Isabel Izquierdo‐Barba, Rafael Samaniego, Jorge Ripoll, Manuel Desco, María Victoria Gómez‐Gaviro   +12 more
wiley   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Inflammatory burden index is correlated with increased depression: a population-based study

BMC Psychiatry
Background Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation.
Xiangzhi Shao, Zuopu Xie, Lielie Zhu
doaj   +1 more source

Downregulation of KRTAP2‐3 Suppresses Proliferation and Tumor Formation of Oral Cancer Cells via Inactivation of KRAS Signals

Cancer Science, EarlyView.
KRTAP2‐3 drives OSCC progression by sustaining both mesenchymal and proliferative properties through KRAS signaling. Loss of KRTAP2‐3 induces MET, suppresses KRAS pathway activation, and markedly reduces tumor cell proiferation and tumor formation as illustarted in Figure.
Qianqian Miao, Zhijun Huang, Kazuki Takahashi, Haruka Ibi, Kohei Miyazono, Katarzyna A. Podyma‐Inoue, Tetsuro Watabe   +6 more
wiley   +1 more source

Calcium mediated functional interplay between myocardial cells upon laser-induced single-cell injury: an in vitro study of cardiac cell death signaling mechanisms

Cell Communication and Signaling, 2020
Background The electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types.
Krishna Chander Sridhar, Nils Hersch, Georg Dreissen, Rudolf Merkel, Bernd Hoffmann   +4 more
doaj   +1 more source

GLP‐1 Receptor Agonists and Risk of Skin Cancer in Adults With Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Existing evidence regarding the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and risk of melanoma and non‐melanoma skin cancer (NMSC) is inconclusive. This study aimed to assess the association between GLP‐1RA initiation and risks of melanoma and NMSC versus sodium–glucose cotransporter 2 inhibitors (SGLT2is ...
Huilin Tang, Bingyu Zhang, Ying Lu, Ting Zhou, Yiwen Lu, César A. Briceño, Jiali Han, Yong Chen   +7 more
wiley   +1 more source

A novel and validated prognostic index in hepatocellular carcinoma: the inflammation based index (IBI).

Journal of Hepatology, 2012
BACKGROUND & AIMS Outcome prediction is uniquely different in hepatocellular carcinoma (HCC) as the progressive functional impairment of the liver impacts patient survival independently of tumour stage.
D. Pinato, J. Stebbing, M. Ishizuka, Shahid A. Khan, H. Wasan, B. North, K. Kubota, Rohini Sharma   +7 more
semanticscholar   +1 more source

A newly discovered Carolingian text: Candidus' Liber testimoniorum veteris testamenti, written for Charlemagne

Early Medieval Europe, EarlyView.
This article presents a newly discovered Latin text: a theological treatise titled Liber testimoniorum veteris testamenti that was written by Alcuin’s friend Candidus (Wizo) at the request of Charlemagne. By discussing selected passages from the Heptateuch, Candidus seeks to demonstrate that Jesus Christ and the Holy Spirit, thus the whole Christian ...
Lukas J. Dorfbauer
wiley   +1 more source