Results 131 to 140 of about 39,319 (333)

Ibrutinib-Associated Atrial Fibrillation

JACC: Clinical Electrophysiology, 2018
Ibrutinib, a novel and potent Bruton tyrosine kinase inhibitor, is an effective and well-tolerated treatment for a variety of B-cell lymphomas. However, its use is associated with an increased incidence of atrial fibrillation (AF), ranging from 4% to 16%. We reviewed the original clinical trials that led to the approval of ibrutinib, as well as several
David M. Venesy, Ana Barac, Tomas G. Neilan, Ghulam M. Chaudhry, Ajay K. Sharma, Sachin P. Shah, Salim S. Hayek, Sarju Ganatra, Syed S. Mahmood, Saurbha Dani, Anju Nohria, Richard D. Patten, John D. Groarke, David Martin   +13 more
openaire   +3 more sources

MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cells. [PDF]

, 2019
Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease.
Aqeel, Rasha, Cagle, Patrice, Chimeh, Uchechukwu, Collins, Sean P, Dahiya, Rajvir, Kumar, Deepak, Niture, Suryakant, Ramalinga, Malathi, Rios-Colon, Leslimar, Srivastava, Anvesha, Suy, Simeng   +10 more
core   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Toxicities and outcomes of 616 ibrutinib-treated patients in the United States: a real-world analysis

Haematologica, 2018
Clinical trials that led to ibrutinib’s approval for the treatment of chronic lymphocytic leukemia showed that its side effects differ from those of traditional chemotherapy.
Anthony R. Mato, Chadhi Nabhan, Meghan C. Thompson, Nicole Lamanna, Danielle M. Brander, Brian Hill, Christina Howlett, Alan Skarbnik, Bruce D. Cheson, Clive Zent, Jeffrey Pu, Pavel Kiselev, Andre Goy, David Claxton, Krista Isaac, Kaitlin H. Kennard, Colleen Timlin, Daniel Landsburg, Allison Winter, Sunita D. Nasta, Spencer H. Bachow, Stephen J. Schuster, Colleen Dorsey, Jakub Svoboda, Paul Barr, Chaitra S. Ujjani   +25 more
doaj   +1 more source

Targeting neoplastic B cells and harnessing microenvironment: the “double face” of ibrutinib and idelalisib [PDF]

, 2015
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not suitable for high dose chemotherapy with autologous stem cell transplantation (ASCT) has a dismal prognosis and no standard therapy.
FIORCARI, STEFANIA, LUPPI, Mario, MAFFEI, Rossana, MARASCA, Roberto, MARTINELLI, Silvia, POTENZA, Leonardo   +5 more
core   +1 more source

Intestinal involvement in graft versus host disease in children: An overview by the ESPGHAN Gastroenterology Committee

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Graft versus host disease (GVHD) is a complication that frequently occurs after haematopoietic stem cell transplantation and concerns many children in paediatric haematology‐oncology and bone marrow transplantation departments. It can affect various organs, with the skin, gastrointestinal tract and liver being the most commonly involved.
Marina Vincent, Amit Assa, Osvaldo Borrelli, Matjaž Homan, Javier Martin‐de‐Carpi, Zrinjka Misak, Maria Giovanna Puoti, Isabelle Scheers, Sara Sila, Caterina Strisciuglio, Christos Tzivinikos, Jernej Dolinsek, Emmanuel Mas   +12 more
wiley   +1 more source

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells [PDF]

, 2015
Background: Roughly 80% of patients with acute myeloid leukaemia have high activity of Bruton's tyrosine-kinase (BTK) in their blast cells compared with normal haemopoietic cells, rendering the cells sensitive to the oral BTK inhibitor ibrutinib in vitro.
Advani, Bendall, Burger, Burnett, Byrd, Chung, Dasmahapatra, de Rooij, de Weers, Dohner, Dos Santos, Dubovsky, Döhner, Fiedler, Fiedler, Gao, Gu, Hahn, Honda, Horwood, Ikeda, Ito, Juliusson, Kim, Koketsu, Kvinlaug, Ma, Matsunaga, Meng, Miettinen, Oellerich, Rushworth, Rushworth, Rushworth, Rushworth, Rushworth, Schmidt, Sivina, Sun, Tai, Tomasson, Wang, Wang, Welch   +43 more
core   +1 more source

Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C‐carbonyls

ChemistryOpen, EarlyView.
Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid used in a proof‐of‐concept study evaluating its utility to trap carbon‐11 (t1/2=20.4 min)‐labeled CO for preparation of amides, ureas and carbamates. Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ...
Anton Lindberg, Narges Mokhtarinori, Zhenzhen Yang, Sheng Dai, Ilja Popovs, Neil Vasdev   +5 more
wiley   +1 more source

Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation

Redox Biology, 2020
Atrial fibrillation (AF) occurs in up to 11% of cancer patients treated with ibrutinib. The pathophysiology of ibrutinib promoted AF is complicated, as there are multiple interactions involved; the detailed molecular mechanisms underlying this are still ...
Xinyu Yang, Na An, Changming Zhong, Manke Guan, Yuchen Jiang, Xinye Li, Hanlai Zhang, Liqin Wang, Yanfei Ruan, Yonghong Gao, Nian Liu, Hongcai Shang, Yanwei Xing   +12 more
doaj