Results 151 to 160 of about 29,210 (297)
Targeting the Ubiquitin–Proteasome System for Cancer
MedComm, Volume 6, Issue 10, October 2025.This figure shows the mechanism of protein degradation by ubiquitin–proteasome system. The process begins with ubiquitin activation by the E1 enzyme, forming a thioester bond between E1's cysteine residue and ubiquitin's glycine carboxyl group, powered by ATP hydrolysis.Zhaoyun Liu, Jiao Lai, Ziyu Ma, Jianhua Pan, Chun Yang, Rong Fu +5 morewiley +1 more sourceThe Impact of Tirabrutinib Monotherapy for the Treatment of Bing‐Neel Syndrome: A Multicenter Retrospective Study
American Journal of Hematology, Volume 100, Issue 10, Page 1912-1915, October 2025.Masuho Saburi, Taro Masunari, Noriko Fukuhara, Yuichiro Inagaki, Arika Shimura, Naoto Imoto, Yuta Hasegawa, Masao Hagihara, Nobuhiko Kobayashi, Hanae Kumekawa, Hideyuki Nakazawa, Kana Miyazaki, Toshiro Kawakita, Takahiro Isshiki, Atsushi Katsube, Shin Fujisawa, Yuichi Horigome, Yusuke Koba, Fumiaki Jinnouchi, Naohiro Sekiguchi +19 morewiley +1 more sourceEgress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients
, 2013 Betty Chang, Michelle Francesco, Martin F. M. de Rooij, Padmaja Magadala, Susanne Steggerda, Min Huang, Annemieke Kuil, Sarah E. M. Herman, Stella Chang, Steven T. Pals, Wyndham H. Wilson, Adrian Wiestner, Marcel Spaargaren, Joseph J. Buggy, Laurence Elias +14 moreopenalex +1 more sourceChemical Engineering of Heterojunction SERS Substrates: Emerging Tools for Disease Diagnosis and Health Monitoring
SmartMat, Volume 6, Issue 5, October 2025.This review summarizes the design, preparation and application of heterojunction SERS substrates, covering various aspects such as environmental monitoring, food safety, and biosensing. It holds significant guiding significance for the development of new SERS substrates and also presents the challenges and future directions of SERS technology ...
Mingjian Zhang, Aochi Liu, Jingyi Zhang, Xiangyu Meng, Yuening Wang, Xiaoyu Song, Yujiao Xie, Lei Xu, Jie Lin, Xiaotian Wang, Jiamin Jin +10 morewiley +1 more sourceSecondary central nervous system lymphoma (SCNSL) in mantle cell lymphoma (MCL): Characteristics and risk factors in a Danish nationwide population‐based study
British Journal of Haematology, Volume 207, Issue 4, Page 1366-1376, October 2025.In a nationwide cohort study, 873 patients with mantle cell lymphoma (MCL) were followed for a median of 7 years. During follow‐up, 28 patients developed secondary central nervous system (CNS) lymphoma (SCNSL) with a 5‐year cumulative incidence of 2.8% (95% confidence interval [CI] 1.7–3.9).Trine Trab, Torgerð Ranadóttir, Iman Chanchiri, Ahmed Ludvigsen Al‐Mashhadi, Emma Berggreen Dall, Stine Rasch, Mette Johansen, Laura Mors Haunstrup, Gabriella Cunsolo, Christian Bjørn Poulsen, Thomas Stauffer Larsen, Simon Husby, Peter Brown, Eliza A. Hawkes, Tarec C. El‐Galaly, Kirsten Grønbæk +15 morewiley +1 more sourcePredictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest
Clinical and Translational Science, Volume 18, Issue 10, October 2025.ABSTRACT
Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang +6 morewiley +1 more sourceKinetics of CLL cells in tissues and blood during therapy with the BTK inhibitor ibrutinib
, 2014 Dominik Wodarz, Naveen Garg, Natalia L. Komarova, Ohad Benjamini, Michael J. Keating, William G. Wierda, Hagop Kantarjian, Danelle F. James, Susan O’Brien, Jan A. Burger +9 moreopenalex +1 more sourceComparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture
HemaSphere, Volume 9, Issue 10, October 2025.Viktoria Kohlhas, Hendrik Jestrabek, Rocio Rebollido‐Rios, Thanh Tung Truong, Anton von Lom, Rebekka Zölzer, Luca D. Schreurs, Duc Pham, Alexander F. vom Stein, Michael Hallek, Phuong‐Hien Nguyen +10 morewiley +1 more source
