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Differential Localization of ICAD-L and ICAD-S in Cells Due to Removal of a C-Terminal NLS from ICAD-L by Alternative Splicing [PDF]
Experimental Cell Research, 2000 CAD/CPAN/DFF40 is an apoptotic nuclease that is associated with the regulatory subunit ICAD/DFF in healthy cells. ICAD has two forms, ICAD-L/DFF45 and ICAD-S/DFF35, which are transcribed from a single gene by alternative splicing. They differ at the C-terminus: 70 amino acids of ICAD-L are replaced by 4 different amino acids in ICAD-S.
Kumiko Samejima, William Earnshaw
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Structure and promoter analysis of murine CAD and ICAD genes [PDF]
Cell Death and Differentiation, 1999 Caspase-activated DNase (CAD) degrades chromosomal DNA during apoptosis, whereas ICAD (inhibitor of CAD) inhibits the CAD's DNase by binding to it. Here, we describe the assignment of murine CAD and ICAD genes to the distal part of murine chromosome 4. Molecular cloning and structural analysis indicated that CAD and ICAD genes are comprised of 7 and 6 ...
Shigekazu Nagata +2 more
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Endovascular treatment for AIS with underlying ICAD
Journal of NeuroInterventional Surgery, 2016BackgroundAcute large vessel occlusion (LVO) can result from thromboemboli or underlying intracranial atherosclerotic disease (ICAD). Although the technique for revascularization differs significantly for these two lesions (simple thrombectomy for thromboemboli and balloon angioplasty and stenting for ICAD), the underlying etiology is often unknown in ...
Sami Al Kasab +6 more
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ICAD/DFF Regulator of Apoptotic Nuclease Is Nuclear
Experimental Cell Research, 1998In nonapoptotic cells, the caspase-activated DNase CAD/CPAN is associated with a regulatory subunit, ICAD/DFF, that binds to it and blocks its enzymatic activity. It has been proposed that a major function of ICAD is to restrain CAD in the cytoplasm in healthy cells.
Kumiko Samejima, William Earnshaw
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Authors' comments on Miner and Caudell, ICAD 1997
ACM Transactions on Applied Perception, 2005Sound is a critical component of multimodal representations of information in virtual environments. Our research program continues to develop and evaluate sound software system architectures, localization techniques, sound synthesis, and musical sonification as tools to enhance human comprehension of complex data sets.
Nadine E. Miner +3 more
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ICADS expert design advisor: an aid to reflective thinking
Knowledge-Based Systems, 1992Abstract An Intelligent Computer Aided Design System ( ICADS ) is under long-term development. Central to this work is the philosophy that the system should be a valuable assistant to the designer throughout the entire design activity. The current working ICADS prototype is a distributive system that can run with a variety of hardware processors in
Leonard Myers, Jens Pohl
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Author's comments on Gröhn, Lokki, and Takala, ICAD 2003
ACM Transactions on Applied Perception, 2005Historical background and motivation for ICAD2003 paper is presented. In addition, the research results followed up is briefly overviewed and future work is elaborated.
Matti Gröhn, Tapio Lokki, Tapio Takala
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ICAD: an appropriate CACSD package for aerospace applications
Proceedings of the 1999 IEEE International Symposium on Computer Aided Control System Design (Cat. No.99TH8404), 2003An analysis and design method, referred to as ICAD, well suited for aerospace control design tasks is outlined. Embodied in a CACSD package, ICAD directly addresses the relevant issues of continuity, simplicity, transparency and flexibility in the modern aerospace MIMO context.
S.S. Robertson +2 more
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