Results 301 to 310 of about 27,302,336 (342)
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Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1
Blood, 2000Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-deficient mice in similar amounts as in ...
N K, van Den Engel +4 more
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Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.
The Journal of Immunology, 1990Abstract We report a methodology for selecting APC with mutations that have impaired their ability to present Ag to T cells. A20 B lymphoblastoid cells were mutagenized and then repeatedly cocultured with murine T-T hybridomas in the presence of specific Ag. During these cocultures, the T-T hybridomas kill the competent APC, allowing the
L H, Dang +4 more
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Cellular Immunology, 1990
We have previously reported that stimulation of human fibroblasts (FB) with interferon-gamma (IFN-gamma) leads to their increased adhesiveness for resting peripheral blood T lymphocytes. With the use of blocking monoclonal antibodies, we determined that intercellular adhesion molecule-1 (ICAM-1) and its T cell ligand, lymphocyte function-associated ...
T H, Piela, J H, Korn
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We have previously reported that stimulation of human fibroblasts (FB) with interferon-gamma (IFN-gamma) leads to their increased adhesiveness for resting peripheral blood T lymphocytes. With the use of blocking monoclonal antibodies, we determined that intercellular adhesion molecule-1 (ICAM-1) and its T cell ligand, lymphocyte function-associated ...
T H, Piela, J H, Korn
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Circulating ICAM-1 in Alcoholic Liver Cirrhosis
International Archives of Allergy and Immunology, 1995The intercellular adhesion molecule 1 (ICAM-1) level in the serum of patients with alcoholic liver cirrhosis was measured using a sandwich enzyme-linked immunosorbent assay. Circulating ICAM-1 was significantly elevated in the sera of all 19 patients as compared with normal healthy subjects. There was no correlation with the Child grade of the disease,
Y, Mándi, I, Nagy
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Clonal senescence alters endothelial ICAM-1 function
Mechanisms of Ageing and Development, 2006Little is known how age alters the dynamics and function of cell adhesion molecules, especially under inflammatory and stressful conditions. One membrane constituent, intercellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein of the immunoglobulin (Ig) superfamily that regulates key outside-->in and inside-->out signals associated with ...
Ximing, Zhou +3 more
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Sequence and expression of rat ICAM-1
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992We have isolated cDNA clones-coding for rat intercellular adhesion molecule-1 (RICAM-1) from a cDNA library constructed from rat Ax cells stimulated with IL-1 beta using the mouse ICAM-1 cDNA as a hybridization probe. The RICAM-1 sequence shows 79.1% homology with mouse ICAM-1 and 55.6% homology with human ICAM-1 at the nucleic acid level.
Y, Kita +5 more
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Endocrinology, 1990
To further understand the mechanism of lymphocyte accumulation within the thyroid gland in autoimmune thyroid disease we have examined the expression, regulation, and functional significance of the intercellular adhesion molecule-1 (ICAM-1, CD54) in human thyroid monolayer cells and immortalized thyroid cell clones.
A, Martin, G K, Huber, T F, Davies
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To further understand the mechanism of lymphocyte accumulation within the thyroid gland in autoimmune thyroid disease we have examined the expression, regulation, and functional significance of the intercellular adhesion molecule-1 (ICAM-1, CD54) in human thyroid monolayer cells and immortalized thyroid cell clones.
A, Martin, G K, Huber, T F, Davies
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Herpesvirus infection of ICAM-1–deficient mice
Current Eye Research, 2004To determine the effect of ICAM-1 deficiency on viral infection of the cornea.Wild-type and intercellular adhesion molecule 1 (ICAM-1)-deficient mice were infected with the RE strain of herpes simplex virus type 1 (HSV-1). Corneal swabs and trigeminal ganglia were obtained and analyzed for infectious virus. Corneas and trigeminal ganglia were evaluated
Hyo W, Jung +6 more
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Targeting LFA-1/ICAM-1 interaction using ICAM-1 binding elastin-like polypeptide
2020Autoimmune diseases are an increasing health care concern. Patients are often prescribed immunosuppressants or steroids that can subdue symptoms, but not cure the disease. Immunosuppressants have shown to be effective for suppressing an overactive immune system, however, increase the chance of infection, cause nausea and overall tiredness or weakness ...
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Physical separation of ICAM-1 binding cells
Journal of Immunological Methods, 1992Studies of interactions between specific molecules involved in adhesion between cells are often complicated since cells possess many different types of surface molecules influencing adhesion. To be able to further study interactions between the adhesive cell surface molecule LFA-1 and its ligand ICAM-1, we have produced an ICAM-1 fusion protein in ...
H, Hedman, H, Brändén, E, Lundgren
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