Results 181 to 190 of about 7,149 (225)

Enzymatic synthesis of anhydroicaritin, baohuoside and icariin

Journal of Asian Natural Products Research, 2022
Anhydroicaritin (1a), baohuoside (1b) and icariin (1c) were recognized as major pharmacologically active ingredients of Epimedium plants. Their primary means of acquisition were chemical isolation from plants. However, it suffers from low yield, environmental pollution and shortage of plants.
Ke-Ping, Feng, Ri-Dao, Chen, Ke-Bo, Xie, Da-Wei, Chen, Ji-Mei, Liu, Jun-Gui, Dai   +5 more
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Pharmacological effects of icariin

2020
Icariin (ICA) is a principal active component from traditional Chinese medicine Epimedium grandiflorum. To explain its traditional medical usages by modern science, a variety of pharmacological effects have been studied for ICA. In this review, we summarized the pharmacokinetics of ICA as well as its pharmacological mechanisms in neurodegenerative ...
Chunyang, He, Ze, Wang, Jingshan, Shi
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Protective Effects of Icariin on Traumatic Brain Injury

Current Neurovascular Research, 2021
Background: Neuroinflammation is central to the pathology of traumatic brain injury (TBI). Icariin (ICA) is a flavonoid derived from the genus Epimedium which is a traditional Chinese herb, a potential therapeutic drug for TBI. This study aims to explore the protective effect of ICA on TBI and its mechanism Methods: Sprague-Dawley rats were ...
Anni, Du, Rui, Cai, Jingshan, Shi, Qin, Wu   +3 more
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Icariin protects against intestinal ischemia–reperfusion injury

Journal of Surgical Research, 2015
This study investigated the role of Sirtuin 1 (SIRT1)/forkhead box O3 (FOXO3) pathway, and a possible protective function for Icariin (ICA), in intestinal ischemia-reperfusion (I/R) injury and hypoxia-reoxygenation (H/R) injury.Male Sprague-Dawley rats were pretreated with different doses of ICA (30 and 60 mg/kg) or olive oil as control 1 h before ...
Feng, Zhang, Yan, Hu, Xiaomei, Xu, Xiaohan, Zhai, Guangzhi, Wang, Shili, Ning, Jihong, Yao, Xiaofeng, Tian   +7 more
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Antiosteoporotic activity of icariin in ovariectomized rats

Phytomedicine, 2009
Icariin was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were divided into sham and OVX groups. The OVX rats were then subdivided into five groups treated with water, nylestriol (1 mg/kg body weight, weekly, orally) or icariin (ICA) (5, 25, and 125 mg/kg body weight, daily, orally) for 12 weeks ...
H, Nian, M-H, Ma, S-S, Nian, L-L, Xu
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Development of Fluorescence-Linked Immunosorbent Assay for Icariin

Journal of Fluorescence, 2017
We have been looking for a faster and simpler method for traditional Chinese medicine and natural product assay. In this study, we developed a fluorescent immunoassay approach to detect icariin (ICA) using a fluorescently labelled monoclonal antibody. The ICA-specific antibody was purified by the caprylic acid-ammonium sulphate method and then labelled
Jinjun, Cheng, Yan, Zhao, Meiling, Zhang, Yue, Zhang, Xiaoman, Liu, Xin, Yan, Yongzhi, Wang, Ziwei, Sun, Qingguo, Wang, Huihua, Qu   +9 more
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Analysis of Biliary Excretion of Icariin in Rats

Journal of Agricultural and Food Chemistry, 2010
Icariin is a bioactive herbal ingredient isolated from Epimedii Herba. This study evaluates the distribution of icariin in rats by microdialysis sampling and high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Microdialysis probes were simultaneously placed in the jugular vein, brain striatum, and bile duct of each anesthetized
Yu-Tse, Wu, Chia-Wen, Lin, Lie-Chwen, Lin, Allen W, Chiu, Kuang-Kuo, Chen, Tung-Hu, Tsai   +5 more
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Synthesis and antibacterial activity of novel icariin derivatives.

Die Pharmazie, 2019
A series of aromatic sulfonyls substituted icariin derivatives was synthesized and their antibacterial activities against S. aureus (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound 9 exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S.
Wang, A., Lili, Lili, Zhang, Zhang, Xu, Y.   +3 more
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Icariin promotes osteogenic differentiation by suppressing Notch signaling

European Journal of Pharmacology, 2019
Osteoporosis is a bone disease characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures. Icariin (ICA), an active flavonoid glucoside isolated from Herba epimedii (HEF), is a potent stimulator of osteogenic differentiation and has potential applications for preventing bone loss in postmenopausal women.
Yuexin, Xu, Lingyun, Li, Yuting, Tang, Jiashu, Yang, Yucui, Jin, Changyan, Ma   +5 more
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Icariin: a potential promoting compound for cartilage tissue engineering [PDF]

Osteoarthritis and Cartilage, 2012
To investigate whether icariin, which is a widely used pharmacological constituent in traditional Chinese herbal medicine, can be a potential promoting compound for cartilage tissue engineering.Icariin was added into cell-hydrogel constructs derived from neonatal rabbit chondrocytes and collagen type I.
Li, D., Yuan, T., Zhang, X., Xiao, Y., Wang, R., Fan, Y., Zhang, X.   +6 more
exaly   +3 more sources