Results 191 to 200 of about 7,149 (225)

HPLC analysis and pharmacokinetics of icariin in rats

Journal of Separation Science, 2007
AbstractAs a prerequisite to the determination of pharmacokinetic parameters of icariin in rats, an HPLC method using UV detection was developed and validated. Icariin and the internal standard, quercetin, were extracted from plasma samples using ethyl acetate after acidification with 0.05 mol/L NaH2PO4 solution (pH 5.0). Chromatographic separation was
Shan, Cheng, Feng, Qiu, Shuhui, Wang, Junqi, He   +3 more
openaire   +2 more sources

A Novel Approach to Utilize Icariin as Icariin-Derived ECM on Small Intestinal Submucosa Scaffold for Bone Repair

Annals of Biomedical Engineering, 2017
Icariin (Ic) has been demonstrated as a potent osteoinductive compound for bone tissue engineering. However, toxic side effects of the drug and poor biocompatibility of drug delivery systems (DDSs) still limit its application for bone repair in the clinic.
Mei Li, Chi Zhang, Yi Zhong, Jiyuan Zhao
openaire   +2 more sources

Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin

Journal of Pharmaceutical and Biomedical Analysis, 2004
A simple and rapid method for determination of icariin (ICA) and its two metabolites, icaritin (ICT) and desmethylicaritin (DICT), by capillary zone electrophoresis has been developed and validated. Optimum separation of ICA, ICT, and DICT was obtained on 43.6 cm x 50 microm capillary using sodium tetraborate (30 mmol/L), monobasic sodium phosphate (50
Jian, Liu, Yi-Jia, Lou
openaire   +2 more sources

Potent Inhibition of Human Phosphodiesterase-5 by Icariin Derivatives

Journal of Natural Products, 2008
Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, and icariin, were screened against phosphodiesterase-5A1 (PDE5A1) activity. Human recombinant PDE5A1 was used as the enzyme source. Only E. brevicornum extract (80%
Dell’Agli M., Galli G., Dal Cero E., BELLUTI, FEDERICA, MATERA, RICCARDO, ZIRONI, ELISA, PAGLIUCA, GIAMPIERO, Bosisio E.   +7 more
openaire   +2 more sources

Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation

International Immunopharmacology, 2019
Microglia-mediated neuroinflammation is an important contributor to the pathogenesis of neurodegenerative diseases. Inhibition of neuroinflammation has been proved to be effective in neurodegenerative diseases treatment. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key mediator of endogenous inducible defense systems in the body. In response
Yaxin, Zheng, Guofu, Zhu, Jingyi, He, Guoqing, Wang, Daidi, Li, Feng, Zhang   +5 more
openaire   +2 more sources

Arsenic Trioxide and Icariin Show Synergistic Anti-leukemic Activity

Cell Biochemistry and Biophysics, 2015
Although As2O3 (ATO) has been recommended as the front-line agent for treatment of acute promyelocytic leukemia (APL), particularly for relapsed or refractory APL, it has been associated with profound toxicity. Icariin is a natural compound with activity against a variety of cancers.
Zhi, Wang, Hong, Zhang, Liling, Dai, Tongguo, Song, Ping, Li, Yali, Liu, Luning, Wang   +6 more
openaire   +2 more sources

[Progress of pharmacological research on icariin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
Icariin (ICA), as one of the flavones compounds, possess strong pharmacological effects. With wide body distribution, it even could pass through blood-brain barrier into brain tissues. When intaken as a pure compound, distribution of ICA in body was accord with open type of two compartment model. If it is one ingredient of a complex prescription, other
Li, Li, Xue-mei, Wang
openaire   +1 more source

Shared KEGG pathways of icariin‐targeted genes and osteoarthritis

Journal of Cellular Biochemistry, 2018
AbstractThe beneficial effects of icariin in the management of many diseases, such as chronic renal failure and heart failure, are well known. Icariin has also been shown to ameliorate osteoarthritis (OA) symptoms; however, the underlying mechanisms remain unclear.
Yi Liu, Bobin Mi, Huijuan Lv, Jing Liu, Yuan Xiong, Liangcong Hu, Hang Xue, Adriana C. Panayi, Guohui Liu, Wu Zhou   +9 more
openaire   +2 more sources

Vasorelaxant Effects of Icariin on Isolated Canine Coronary Artery

Journal of Cardiovascular Pharmacology, 2007
Owing to its cardiovascular therapeutical effects, icariin, a flavonoid isolated from Epimedii herba, is considered to be the major active constituent of Epimedii herba. The aim of this study is to investigate the effect of icariin on precontracted coronary artery isolated from canine.
Hai-Bin, Xu, Zhao-Quan, Huang
openaire   +2 more sources

Icariin: A Potential Osteoinductive Compound for Bone Tissue Engineering

Tissue Engineering Part A, 2010
To effectively treat bone diseases using bone regenerative medicine, there is an urgent need to develop safe and cheap drugs that can potently induce bone formation. Here, we demonstrate the osteogenic effects of icariin, the main active compound of Epimedium pubescens. Icariin induced osteogenic differentiation of preosteoblastic cells.
Jiyuan, Zhao, Shinsuke, Ohba, Yusuke, Komiyama, Masashige, Shinkai, Ung-il, Chung, Teruyuki, Nagamune   +5 more
openaire   +2 more sources