Results 61 to 70 of about 162,386 (264)

Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development

Journal of Mind and Medical Sciences
Introduction. Interstitial Cells of Cajal (ICCs) play a critical role in the regulation of gastrointestinal motility and have been implicated in various functional gastrointestinal disorders.
Petru Radu, Mihai Zurzu, Anca Tigora, Vlad Paic, Mircea Bratucu, Dragos Garofil, Valeriu Surlin, Stefan Patrascu, Virgiliu Prunoiu, Ionut Simion Coman, Valentin Georgescu, Razvan Daniel Chivu, Florian Popa, Victor Strambu, Raluca Gabriela Ioan   +14 more
doaj   +1 more source

Aggravating Circumstances in the Sentencing Process of International Crimes [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2015
International crimes such as genocide, crimes against humanity and etc. bring severe effects and disastrous consequences. Subsequently, these are also to the same degree reprehensible, and criminal reaction of states in the form of universal jurisdiction
Behzad Razavi fard
doaj  

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Study of phosphorylated ribosomal protein S6 (pS6) in the clinical outcomes of patients undergoing hepatectomy for metastatic colorectal cancer

World Journal of Surgical Oncology
Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with up to 50% of patients developing metastatic disease, predominantly involving the liver. Hepatectomy remains the gold standard for resectable hepatic metastases;
Rafaella Henriques Cavalcanti Torres de Melo, Paulo Goberlianio de Barros Silva, Heladio Feitosa e Castro Neto, Rayane Cardoso de Souza Nunes, José Ricardo de Moura Torres de Melo, Maria Julia Barbosa Bezerra, Conceição Aparecida Dornelas, Carlos Gustavo Hirth   +7 more
doaj   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Ingrid Roestenburg-Morgan. 2022. The road to reconciliation? Optimizing the legitimacy and efficacy of the International Criminal Court within the African Union and Africa. Louvain-la-Neuve: Larcier Intersentia, Human Rights Research Series 102. 411 p.

Deusto Journal of Human Rights
The book provides a rigorous multi-disciplinary analysis of the ingrained tensions between the International Criminal Court (ICC) and the African Union (AU) related to a crisis of legitimacy of the ICC in the continent.
Davinia Gómez Sánchez
doaj   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

The Terminology Work of IFIP and ICC [PDF]

The Computer Journal, 1964
The preparation of a multilingual vocabulary of a specialized subject (namely, Automatic Data Processing), presents difficulties, some of which are described. The methods of the International Federation for Information Processing and the International Computation Centre separate and clarify these difficulties, and constitute an advance in the technique
I. H. Gould, G. C. Tootill
openaire   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source