Results 81 to 90 of about 558,057 (306)

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

open access: yesAdvanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo   +14 more
wiley   +1 more source

Aggravating Circumstances in the Sentencing Process of International Crimes [PDF]

open access: yesFaṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2015
International crimes such as genocide, crimes against humanity and etc. bring severe effects and disastrous consequences. Subsequently, these are also to the same degree reprehensible, and criminal reaction of states in the form of universal jurisdiction
Behzad Razavi fard
doaj  

Opportunities to Develop Intercultural Communicative Competence in Czech lower-secondary schools: Findings of the IRSE Video Study of German

open access: yesJournal of Language and Cultural Education, 2018
The empirical study deals with the topic of teaching intercultural communicative competence (ICC) in Czech lower-secondary German classes. The aim of the study is to investigate the quantity and quality of the opportunities to develop ICC, the proportion
Zerzová Jana
doaj   +1 more source

Interstitial cell network volume is reduced in the terminal bowel of ageing mice [PDF]

open access: yes, 2018
Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence.
Gamage, Prasanna P. K. M.   +4 more
core   +3 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji   +10 more
wiley   +1 more source

Colorimetrically accurate color accounting and external conditions of perception television image

open access: yesФизика волновых процессов и радиотехнические системы, 2014
It is shown that color chromaticity coordinates, which are inside the triangle gamut screen television may play a colorimetric exactly, i. e. without color distortion.
L.D. Lozhkin   +2 more
doaj  

China – ICC arbitration in China [PDF]

open access: yes, 2000
Letter from barrister Anthony Connerty describing one of the few international commercial arbitration hearings to be held in China under the Rules of the International Chamber of Commerce which took place in Beijing in February 1999.
Connerty, Anthony
core  

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

open access: yesAdvanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen   +13 more
wiley   +1 more source

Muppets and gazelles: political and methodological biases in entrepreneurship research [PDF]

open access: yes, 2013
Despite an almost universally accepted belief outside academia that entrepreneurial activity is a positive driving force in the economy, the accumulated evidence remains largely inconclusive.
Coad, Alex, Nightingale, Paul
core   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

open access: yesAdvanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang   +8 more
wiley   +1 more source

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