Results 191 to 200 of about 306,492 (342)

Coupled ice sheet–climate modeling under glacial and pre-industrial boundary conditions

, 2014
Florian Ziemen, Christian Rodehacke, Uwe Mikolajewicz   +2 more
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Projections of 21st-century sea-level fall along coastal Greenland. [PDF]

Nat Commun
Lewright L, Austermann J, Piecuch CG, Adhikari S, Davis JL, Milne GA, Paxman GJG.   +6 more
europepmc   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

From short-term uncertainties to long-term certainties in the future evolution of the Antarctic Ice Sheet. [PDF]

Nat Commun
Coulon V, Klose AK, Edwards T, Turner F, Pattyn F, Winkelmann R.   +5 more
europepmc   +1 more source

ISMIP6 future projections for Greenland and Antarctica with the ice sheet model SICOPOLIS

, 2019
Ralf Greve, Christopher Chambers, Reinhard Calov, Takashi Obase, Fuyuki Saito, Shun Tsutaki, Ayako Abe‐Ouchi   +6 more
openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Bedrock uplift reduces Antarctic sea-level contribution over next centuries. [PDF]

Nat Commun
van Calcar CJ, Bernales J, Berends CJ, van der Wal W, van de Wal RSW.   +4 more
europepmc   +1 more source

Extracting Dated Isochrones on Airborne Radar Data Across EastAntarctica for Input into 3-D Regional Ice Sheet Models

Julien A. Bodart, Vjeran Višnjević, Antoine Hermant, Johannes Sutter   +3 more
openalex   +1 more source

Modelled ice-sheet margins of three Greenland ice-sheet models compared with a geological record from ice-marginal deposits in central West Greenland [PDF]

, 1996
Frank G. M. Van Tatenhove, Adeline Fabre, Ralf Greve, Philippe Huybrechts   +3 more
openalex   +1 more source