Results 201 to 210 of about 306,492 (342)

First application of artificial neural networks to estimate 21st century Greenland ice sheet surface melt: scripts and models

, 2021
Raymond Sellevold
openalex   +2 more sources

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Repeated major inland retreat of Thwaites and Pine Island glaciers (West Antarctica) during the Pliocene. [PDF]

Proc Natl Acad Sci U S A
Horikawa K, Iwai M, Hillenbrand CD, Siddoway CS, Halberstadt AR, Cowan EA, Penkrot ML, Gohl K, Wellner JS, Asahara Y, Shin KC, Noda M, Fujimoto M, Expedition 379 Science Party.   +13 more
europepmc   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

Sequence of abrupt transitions in Antarctic drainage basins before and during the Mid-Pleistocene Transition. [PDF]

Nat Commun
Wirths C, Hermant A, Stepanek C, Stocker TF, Sutter JCR.   +4 more
europepmc   +1 more source

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Mid Holocene rapid thinning and rethickening of the East Antarctic ice sheet suggested by glacial isostatic adjustment. [PDF]

Sci Rep
Okuno J, Hattori A, Doi K, Aoyama Y, Fukuda Y.   +4 more
europepmc   +1 more source

Modelling the Eurasian Ice Sheet

Conference lecture at the international conference "Glacial evolution of the north European ice sheets during the Quaternary: Status and Challenges", 15.03.24, Trondheim, Norway.
openaire   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Difference between initial submission and revision for "Assessment of Sub-Shelf Melting Parameterisations Using the Ocean-Ice Sheet Coupled Model NEMO(v3.6)-Elmer/Ice(v8.3)" by Favier et al.

, 2019
Lionel Favier
openalex   +1 more source