Results 231 to 240 of about 306,492 (342)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Surface freshening in the subpolar North Atlantic sustaining the weakened AMOC during the late Younger Dryas. [PDF]

Sci Adv
You D, Stein R, Lohmann G, Masoum A, Fahl K, Wu J, Jackson R.   +6 more
europepmc   +1 more source

Review of “A new bed elevation model for the Weddell Sea sector of the West Antarctic Ice Sheet” by H. Jeofry et al.

, 2017

openalex   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

Advanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu   +18 more
wiley   +1 more source

Electrostatic Defrosting. [PDF]

Small Methods
Lolla VY, Zhang H, Socha BZ, Qiao R, Boreyko JB.   +4 more
europepmc   +1 more source

A Factor Two Difference in 21st-Century Greenland Ice Sheet Surface Mass Balance Projections from Three Regional Climate Models for a Strong Warming Scenario (SSP5-8.5) [PDF]

Quentin Glaude, Brice Noël, Martin Olesen, M. R. van den Broeke, Willem Jan van de Berg, Ruth Mottram, Nicolaj Hansen, Alison Delhasse, Charles Amory, Christoph Kittel, Heiko Goelzer, Xavier Fettweis   +11 more
openalex   +1 more source

Ice-sheet model sensitivities to environmental forcing and their use in projecting future sea level (the SeaRISE project)

Journal of Glaciology, 2013
R. Bindschadler, S. Nowicki, A. Abe‐Ouchi, A. Aschwanden, Hyeungu Choi, J. Fastook, G. Granzow, R. Greve, G. Gutowski, U. Herzfeld, C. Jackson, Jesse Johnson, C. Khroulev, A. Levermann, W. Lipscomb, M. Martin, Mathieu Morlighem, B. Parizek, D. Pollard, S. Price, D. Ren, F. Saito, Tatsuru Sato, H. Seddik, H. Seroussi, Kunio T. Takahashi, R. Walker, Wei Li Wang   +27 more
semanticscholar   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Contrasting melt regime in the Ice Grounding Zone of Thwaites Glacier, West Antarctica. [PDF]

Proc Natl Acad Sci U S A
Gadi R, Rignot E, Menemenlis D, Scheuchl B.   +3 more
europepmc   +1 more source

Quantifying the effect of ocean bed properties on ice sheet geometryover 40,000 years with a full-Stokes model

, 2020
Clemens Schannwell, Reinhard Drews, Todd A. Ehlers, Olaf Eisen, C. Mayer, Mika Malinen, Emma C. Smith, Hannes Eisermann   +7 more
openalex   +1 more source