Results 131 to 140 of about 2,666,636 (245)

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Microstructure Evolution in Dry‑Coated Sulfidic All‐Solid‐State Battery Cathodes: Investigating Core–Shell Particle Morphology

Advanced Science, EarlyView.
Mixing method directly governs interface engineering and electrode morphology during the dry coating of all‐solid‐state battery cathodes. While high‐shear batch mixing yields poor electrode quality and lacks core–shell‐like features, continuous extruder mixing enables strong binder fibrillation and a core–shell‐like coating between the active material ...
Michael Wolf, Aaron Stoeckle, Rebecca Wilhelm, Maximilian A. Plass, Milad Hosseini, Johannes Kriegler, Korbinian Huber, Simon Lux   +7 more
wiley   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

Advanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo, Cheng‐Chen Hou, Wei Wang, Ya‐Xuan Zhu, Ling Li, Li‐Juan Liu, Chuan‐Jian Lu, Peng‐Fei Tu, Yang Liu, Rui‐Zhi Zhao, Ke‐Wu Zeng   +10 more
wiley   +1 more source

Prepolymerization Enables On‐Demand Viscosity Tuning for Xolography of Soft Hydrogels

Advanced Science, EarlyView.
A facile in situ prepolymerization strategy enables on‐demand viscosity tuning across three orders of magnitude without external thickeners, transforming low‐viscosity resins into printable formulations for Xolography. The approach suppresses sedimentation, lowers curing dose, enables high‐fidelity support‐free fabrication, and produces advanced ...
Xichuan Li, Marcus Reuter, Linguangze Zhuo, Xueheng Dai, Camille Tribout, Nathaniel Corrigan, Jin Zhang, Cyrille Boyer   +7 more
wiley   +1 more source

Biobased Boston Ivy‐Inspired Cryogel Integrating Radiative Cooling and Phase Change Energy Storage for Adaptive Thermal Regulation

Advanced Science, EarlyView.
A bionic cryogel containing phase‐change materials that provides daytime radiative cooling and nighttime heat release is developed to promote environmentally sustainable and comfortable housing and living environments with reduced building energy demand.
Sining Huang, Zhiguo Li, Yang Liu, Chengyu Wang, Yi Lu, Erlantz Lizundia, Siqi Huan   +6 more
wiley   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Mass balance of the Greenland and Antarctic ice sheets from the 1970s to 2023. [PDF]

Sci Data
Otosaka IN, Shepherd A, Amory C, Horwath M, Ivins ER, King MD, Nowicki S, Payne AJ, Rignot E, Sørensen LS, Schlegel NJ, Simon KM, Smith BE, Sutterley TC, van den Broeke MR, Velicogna I, A G, Agosta C, Ditmar P, Döhne T, Engdahl ME, Fettweis X, Forsberg R, Gardner AS, Gilbert L, Goelzer H, Gourmelen N, Groh A, Hansen N, Harig C, Helm V, Khan SA, Kittel C, Langen PL, Larsen M, Loomis BD, McMillan M, Medley B, Melini D, Mottram RH, Muir A, Nilsson J, Noël B, Pattle ME, Roca I Aparici M, Sasgen I, Save HV, Scheuchl B, Schrama EJO, Schröder L, Seo KW, Simonsen SB, Slater T, Spada G, Vishwakarma BD, Wever N, Wiese DN, Wouters B.   +57 more
europepmc   +1 more source

Combined Immune‐Peptide Nanofiber with HSP70/AKT/mTOR Axis Blockade Enhances Photothermal Immunotherapy, Inhibiting Tumor Growth and Recurrence

Advanced Science, EarlyView.
A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang, Zhenqi Jiang, Wenjia Zhang, Juncheng Wu, Haozhuo Guo, Changlei Li, Mingwei Sun, Xiaoying Tang, Yue Zhang, Wei Huang, Huadan Xue, Yang Du   +11 more
wiley   +1 more source