Results 151 to 160 of about 3,902,696 (360)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A physically-based formulation for texture evolution during dynamic recrystallization. A case study of ice

Comptes Rendus. Mécanique
Dynamic recrystallization can have a strong impact on texture development during the deformation of polycrystalline materials at high temperatures, particularly for materials with strong viscoplastic anisotropy such as ice.
Chauve, Thomas, Montagnat, Maurine, Dansereau, Véronique, Saramito, Pierre, Fourteau, Kévin, Tommasi, Andréa   +5 more
doaj   +1 more source

Some Glorious and Incomparable Promises of the Bible [PDF]

, 2009
During the first half of World War II General Douglas MacArthur was forced to leave the Philippines in the Pacific Theater by the Japanese. Upon his departure he made a promise to the Philippino people: “I will return.” General MacArthur, through the ...
Ice, Thomas D.
core  

Seeing the light : experimental signatures of emergent electromagnetism in a quantum spin ice

, 2012
The "spin ice" state found in the rare earth pyrochlore magnets Ho2Ti2O7 and Dy2Ti2O7 offers a beautiful realisation of classical magnetostatics, complete with magnetic monopole excitations.
K. Penc, L.-J. Chang, Nic Shannon, Olga Sikora, Owen Benton   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Quantification of segregation dynamics in ice mixtures

, 2009
(Abridged) The observed presence of pure CO2 ice in protostellar envelopes is attributed to thermally induced ice segregation, but a lack of quantitative experimental data has prevented its use as a temperature probe. Quantitative segregation studies are
Bergin, Bergin, Bernstein, Bouwman, Chiar, Collings, Collings, Cuppen, Dartois, E. C. Fayolle, E. F. van Dishoeck, Ehrenfreund, Ehrenfreund, Fuchs, Garrod, Gerakines, Gerakines, Gerakines, H. Linnartz, H. M. Cuppen, Hodyss, Ioppolo, Jenniskens, K. I. Öberg, Knez, Loeffler, Los, Los, Merrill, Nummelin, Palumbo, Pontoppidan, Pontoppidan, Sandford, Sonnentrucker, Teolis, Tielens, van Broekhuizen, Visser, Watanabe, Watanabe, Zasowski, Öberg, Öberg   +43 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Modelling the atomic structure of very high-density amorphous ice

, 2005
The structure of very high-density amorphous (VHDA) ice has been modelled by positionally disordering three crystalline phases, namely ice IV, VI and XII.
Benmore, C. J., Christie, J. K., Elliott, S. R., Guthrie, M., Klug, D. D., Taraskin, S. N., Tulk, C. A.   +6 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source