Results 91 to 100 of about 45,044 (305)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Application of Extended Messinger Models to Complex Geometries [PDF]

open access: yes
Since, ice accretion can significantly degrade the performance and the stability of an airborne vehicle, it is imperative to be able to model it accurately.
Gupta, Avani   +2 more
core   +1 more source

Cooperative Origin of Low-Density Domains in Liquid Water

open access: yes, 2002
We study the size of clusters formed by water molecules possessing large enough tetrahedrality with respect to their nearest neighbors. Using Monte Carlo simulation of the SPC/E model of water, together with a geometric analysis based on Voronoi ...
C. A. Angell   +10 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

LEWICE/E: An Euler based ice accretion code [PDF]

open access: yes
A new version of the LEWICE ice accretion computer code was developed which calculates the ice growth on two dimensional surfaces, incorporating the effects of compressibility through the solution of the Euler equations.
Potapczuk, Mark G.
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Unprecedented Vessel-Icing Climatology Based on Spray-Icing Modelling and Reanalysis Data: A Risk-Based Decision-Making Input for Arctic Offshore Industries

open access: yesAtmosphere, 2019
Marine icing is considered a major concern for vessels operating in the Arctic Ocean. Interaction between vessels and waves is the major source of sea spray that, under certain conditions, can lead to ice accretion on the vessels and thus create ...
Masoud Naseri, Eirik Mikal Samuelsen
doaj   +1 more source

The UH-1H helicopter icing flight test program: An overview [PDF]

open access: yes
An ongoing joint NASA/Army program to study the effects of ice accretion on unprotected helicopter rotor aerodynamic performance is discussed. This program integrates flight testing, wind tunnel testing, and analytical modeling. Results are discussed for
Richter, G. P., Shaw, R. J.
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Ice Accretion in Freezing Rain. [PDF]

open access: yes, 1996
Abstract : Ice accreted on structures from freezing rain causes both increased vertical loads and increased wind loads, due to the larger projected area of the structure. Structural failures initiated by ice loads frequently cause millions of dollars of damage to overhead power and communication lines, towers, and other ice-sensitive structures.
openaire   +1 more source

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