Results 101 to 110 of about 45,044 (305)
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source
A mathematical model based on unstructured mesh for ice accretion
AIP Advances, 2019 This paper proposes a three-dimensional model to simulate ice accretion on the surface of an aircraft. The model is developed using a prism grid cell, which enables iterations with an unstructured mesh.
Ningli Chen +4 more
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Swept wing ice accretion modeling [PDF]
An effort to develop a three-dimensional modeling method was initiated. This first step towards creation of a complete aircraft icing simulation code builds on previously developed methods for calculating three-dimensional flow fields and particle ...
Bidwell, Colin S., Potapczuk, Mark G.
core +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Applied SciencesGondolas are a useful mode of transportation in the mountainous regions. In regions located at high altitudes, atmospheric icing is a significant safety hazard to gondola infrastructure. In this study, multiphase numerical simulations of ice accretion on
Hamza Asif +3 more
doaj +1 more source
The growth of planets by pebble accretion in evolving protoplanetary discs
, 2015 The formation of planets depends on the underlying protoplanetary disc structure, which influences both the accretion and migration rates of embedded planets. The disc itself evolves on time-scales of several Myr during which both temperature and density
Bitsch, Bertram +2 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles +14 more
wiley +1 more source
Comparison of Two Ice and Snow Storm Processes in China in February 2024
应用气象学报Two ice and snow storm processes hit middle and eastern China during 31 January to 7 February (Process Ⅰ) and 19 February to 25 February (Process Ⅱ) in 2024, which are the most extreme ice and snow events since 2009.
Dong Quan +6 more
doaj +1 more source