Results 91 to 100 of about 150,822 (249)

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Tropical ocean-atmosphere controls on inter-annual climate variability in the Cretaceous Arctic

, 2011
The first annually resolved sedimentary record from the Cretaceous is used to develop time series of inter-annual and decadal scale climate variability from the Arctic Ocean.
Kemp, Alan E.S., Heiko Pälike, Davies, Andrew, Pälike, Heiko, Alan E. S. Kemp, Andrew Davies   +5 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Saharan dust and ice nuclei over Central Europe [PDF]

, 2010
Surface measurements of aerosol and ice nuclei (IN) at a Central European mountain site during an episode of dust transport from the Sahara are presented.
B. Nillius, Levin, Zev, Barrie, Leonard A., Nillius, Björn, M. Ebert, Bingemer, Heinz, S. Weinbruch, Ebert, Martin, Nickovic, Slobodan, Haunold, Werner, H. Klein, U. Bundke, Klein, Holger, Bundke, Ulrich, Weinbruch, Stephan, H. Bingemer, L. Schuetz, Z. Levin, Schuetz, Lothar, L. A. Barrie, S. Nickovic, W. Haunold   +21 more
core   +2 more sources

Quantifying the trade-offs between renewable energy visibility and system costs

Nature Communications
Visual landscape impacts on scenic and populated places are among significant factors affecting local acceptance of large-scale renewable energy projects. Through the combination of large-scale reverse viewshed and techno-economic energy system analyses,
Tsamara Tsani, Tristan Pelser, Romanos Ioannidis, Rachel Maier, Ruihong Chen, Stanley Risch, Felix Kullmann, Russell McKenna, Detlef Stolten, Jann Michael Weinand   +9 more
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Changing climate and rising seas: understanding the science [PDF]

, 2014
An investigation of what is causing climate change and one of its major impacts – the rising level of the sea. Introduction The level of the sea is constantly changing everywhere on Earth as tides rise and fall in predictable patterns.
Parliamentary Commissioner for the Environment
core  

The effect of a Holocene climatic optimum on the evolution of the Greenland ice sheet during the last 10 kyr

Journal of Glaciology, 2018
The Holocene climatic optimum was a period 8–5 kyr ago when annual mean surface temperatures in Greenland were 2–3°C warmer than present-day values. However, this warming left little imprint on commonly used temperature proxies often used to derive the ...
LISBETH T. NIELSEN, GUðFINNA AÐALGEIRSDÓTTIR, VASILEIOS GKINIS, ROMAN NUTERMAN, CHRISTINE S. HVIDBERG   +4 more
doaj   +1 more source