Results 71 to 80 of about 150,822 (249)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Improving the spatial distribution of modeled Arctic sea ice thickness [PDF]

, 2005
The spatial distribution of ice thickness/draft in the Arctic Ocean is examined using a sea ice model. A comparison of model predictions with submarine observations of sea ice draft made during cruises between 1987 and 1997 reveals that the model has the
Laxon, SW, Miller, PA, Feltham, DL, Laxon, S. W., Feltham, D. L., Miller, P. A.   +5 more
core   +1 more source

Voltage scanning to calibrate Multi-Reagent Chemical Ionization Mass Spectrometers (MR-CIMS): from signal to sensitivity [PDF]

Atmospheric Measurement Techniques
Chemical ionization mass spectrometry (CIMS) offers high time-resolution measurements for diverse compounds, but atmospheric quantification remains challenging.
Y. Wang, A. Voliotis, A. Voliotis, E. Matthews, R. Wu, M. Roska, M. G. Adam, R. Dubus, L. Kesper, F. Rohrer, R. Wegener, B. Winter, K. H. Bates, Q. He, T. Hohaus, A. Grasse, R. Tillmann, A. Wahner, H. Wang, C. Wesolek, S. Wedel, Y. Wu, S. R. Zorn, M. Canagaratna, D. Worsnop, F. Lopez-Hilfiker, G. I. Gkatzelis, H. Coe, H. Coe, T. J. Bannan   +29 more
doaj   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Reviewing the complexity of endogenous technological learning for energy system modeling

Advances in Applied Energy
Energy system components like renewable energy technologies or electrolyzers are subject to decreasing investment costs driven by technological progress.
Johannes Behrens, Elisabeth Zeyen, Maximilian Hoffmann, Detlef Stolten, Jann M. Weinand   +4 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Climate change 2013: the physical science basis [PDF]

, 2013
This report argues that it is extremely likely that human influence has been the dominant cause of the observed warming since the mid-20th century. This is an an unedited version of the Intergovernmental Panel on Climate Change\u27s Working Group I ...

core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Chlorine peroxide reaction explains observed wintertime hydrogen chloride in the Antarctic vortex

Communications Earth & Environment
It is well established that the drastic ozone loss in the Antarctic stratosphere, commonly known as the ozone hole, is primarily driven by gas-phase and heterogeneous chemical processes. While chemistry transport models generally reproduce observed ozone
Jens-Uwe Grooß, Rolf Müller, John N. Crowley, Michaela I. Hegglin   +3 more
doaj   +1 more source