Results 51 to 60 of about 605,233 (331)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Stranger to familiar: wild strepsirhines manage xenophobia by playing. [PDF]

PLoS ONE, 2010
The power of play in limiting xenophobia is a well-known phenomenon in humans. Yet, the evidence in social animals remains meager. Here, we aim to determine whether play promotes social tolerance toward strangers in one of the most basal group of ...
Daniela Antonacci, Ivan Norscia, Elisabetta Palagi   +2 more
doaj   +1 more source

Planning long-term maintenance for electric vehicle charging infrastructure using the Reliability Centered Maintenance (RCM) method [PDF]

, 2012
Electric vehicles (EVs) are mainly known for their advantages as emission free, energy efficient and noiseless transport, but electric mobility has never matured in the automotive market and it remains in the shadow of the internal combustion engine (ICE)
LIOCE, LUIGI
core  

Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit [PDF]

, 2011
The volatile compounds that constitute the fruit aroma of ripe tomato (Solanum lycopersicum) are often sequestered in glycosylated form. A homology-based screen was used to identify the gene SlUGT5, which is a member of UDP-glycosyltransferase 72 family ...
Alba, Baldwin, Birtic, Bowles, Brazier-Hicks, Brazier-Hicks, Brazier-Hicks, Buttery, Chervin, Fleuriet, Fukuchi-Mizutani, Gachon, Hansen, Hefner, Jones, Jones, Jugdé, Kino, Lairson, Lairson, Lanot, Lanot, Li, Lim, Loutre, Lunkenbein, Marlatt, Morris, Ortiz-Serrano, Pang, Ross, Sali, Schuettelkopf, Shimoda, Smart, Song, Syahrani, Tikunov, Wang, Witte, Yoon, Zanor   +41 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pengaruh Model Pembelajaran Arias dengan Selingan Ice Breaker terhadap Hasil Belajar IPA

Jurnal Ilmiah Sekolah Dasar, 2018
This study is aimed at finding out the significant difference of natural science learning result between group of students who took the ARIAS learning with an ice breaker model and group of students who took conventional learning on the fifth grade ...
Ni made Pratiwi satriani, Ketut Pudjawan, I. M. Suarjana   +2 more
semanticscholar   +1 more source

Reflections on trauma and the process of researching and writing the histories and memories of the Holocaust [PDF]

, 2013
This paper was delivered at the University of Zaragoza, 'Acts of Remembrance' conference (24-26 April 2013) as part of Dr Allwork and Dr Sonya Andermahr's Santander sponsored trip to promote the Working Group for Interdisciplinary Research in Trauma ...
Allwork, Larissa
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Evaluation of the ArcIOPS sea ice forecasts during 2021–2023

Frontiers in Earth Science
The operational sea ice forecasts from the Arctic Ice Ocean Prediction System (ArcIOPS) during 2021–2023 are validated against satellite-retrieved sea ice concentration and drift data, in situ and reanalyzed sea ice thickness data.
Xi Liang, Zhongxiang Tian, Fu Zhao, Ming Li, Na Liu, Chunhua Li   +5 more
doaj   +1 more source

Activities of the training vessel Umitaka-maru (KARE-17; UM-13-09) of the Tokyo University of Marine Science and Technology during the 55th Japanese Antarctic Research Expedition in 2013/2014

Antarctic Record, 2016
A marine science cruise was undertaken in the Indian sector of the Southern Ocean during the 2012/2013 austral summer on the training vessel Umitaka-maru (KARE-17; UM-13-09) of the Tokyo University of Marine Science and Technology (TUMSAT).
Masato Moteki
doaj   +1 more source