Results 161 to 170 of about 815,112 (296)

Tracing stratospheric transport using subannual plutonium-239 fallout in polar ice cores. [PDF]

Sci Adv
Shin J, Lee S, Han Y, Hwang H, Ro S, Do Hur S, Hong SB.   +6 more
europepmc   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

From ice cores to dinosaurs: physical collections managers' research data curation perceptions and behaviors. [PDF]

PLoS One
Bishop BW, Fox J, Gavel SWT, Chapin EG, Kansa S.   +4 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Carbonaceous aerosol tracers in ice-cores record multi-decadal climate oscillations. [PDF]

Sci Rep, 2015
Seki O, Kawamura K, Bendle JA, Izawa Y, Suzuki I, Shiraiwa T, Fujii Y.   +6 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

State dependence of climatic instability over the past 720,000 years from Antarctic ice cores and climate modeling. [PDF]

Sci Adv, 2017
Dome Fuji Ice Core Project Members:, Kawamura K, Abe-Ouchi A, Motoyama H, Ageta Y, Aoki S, Azuma N, Fujii Y, Fujita K, Fujita S, Fukui K, Furukawa T, Furusaki A, Goto-Azuma K, Greve R, Hirabayashi M, Hondoh T, Hori A, Horikawa S, Horiuchi K, Igarashi M, Iizuka Y, Kameda T, Kanda H, Kohno M, Kuramoto T, Matsushi Y, Miyahara M, Miyake T, Miyamoto A, Nagashima Y, Nakayama Y, Nakazawa T, Nakazawa F, Nishio F, Obinata I, Ohgaito R, Oka A, Okuno J, Okuyama J, Oyabu I, Parrenin F, Pattyn F, Saito F, Saito T, Saito T, Sakurai T, Sasa K, Seddik H, Shibata Y, Shinbori K, Suzuki K, Suzuki T, Takahashi A, Takahashi K, Takahashi S, Takata M, Tanaka Y, Uemura R, Watanabe G, Watanabe O, Yamasaki T, Yokoyama K, Yoshimori M, Yoshimoto T.   +64 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source