Results 201 to 210 of about 562,841 (289)

High Arctic lakes reveal accelerating ecological shifts linked to twenty-first century warming. [PDF]

Sci Rep
Cameron E, Oliva M, Antoniades D.
europepmc   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Biomarker <i>δ</i>¹³C values record consistent savanna vegetation and variable alkalinity of Lake Olduvai during Pleistocene wet/dry cycles. [PDF]

Proc Natl Acad Sci U S A
Doiron KE, Colcord DE, Shilling AM, Njau JK, Stanistreet IG, Stollhofen H, Schick KD, Toth NP, Brassell SC.   +8 more
europepmc   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Southern Ocean seabird population shifts over the Holocene revealed by peat sequestration of mercury from guano. [PDF]

Proc Natl Acad Sci U S A
Li C, Roberts SJ, Grosjean M, Mestrot A, Wille M, Phillips RA, Enrico M, Bishop K, Skyllberg U, Mauquoy D, von Scheffer C, Theurer T, Muirhead D, Whittle A, Gallego-Sala A, Sonke JE, De Vleeschouwer F, Van der Putten N, Braconnot P, Marti O, Osterwalder S, Buchmann N, Frölicher T, Anthamatten E, Chiaia-Hernández AC, Zahajská P, Jeandel C, Saunders KM, Kwon SY, Wang D, Bindler R, Sime L, Hodgson DA.   +32 more
europepmc   +1 more source

Nickel Intercalation in Epitaxial Graphene on SiC(0001): A Novel Platform for Engineering Two‐Dimensional Heterostructures

Advanced Science, EarlyView.
Ni‐intercalated graphene on SiC is achieved through a scalable colloidal nanoparticle deposition route. 2D heterostructures show preserved graphene band structure, stable under ambient conditions, and robust interfacial magnetism. Intercalated 2D Ni represents a promising candidate for next‐generation spintronic devices and is a scalable pathway to ...
Ylea Vlamidis, Stiven Forti, Antonio Rossi, Arrigo Calzolari, Carmela Marinelli, Camilla Coletti, Stefan Heun, Stefano Veronesi   +7 more
wiley   +1 more source

Past intrusion of Circumpolar Deep Water in the Ross Sea: Impacts on the ancient Ross Ice Shelf. [PDF]

Sci Adv
Pambianco C, Nogarotto A, Sabino M, Capotondi L, Battaglia F, Giglio F, Mollenhauer G, Hefter J, Di Roberto A, Belt ST, Pochini E, Muschitiello F, Geniram A, Colizza E, Giorgetti G, Torricella F, Tesi T.   +16 more
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Nanoplastic concentration and potential transport in the Arctic Ocean. [PDF]

NPJ Emerg Contam
Cai H, Carrier-Belleau C, Guilmette C, Massicotte P, Luthi-Maire A, Gigault J.   +5 more
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source