Results 231 to 240 of about 24,371 (312)

The contribution of sea-ice recrystallization to the Arctic snowpack. [PDF]

Nat Commun
Macfarlane AR, Mellat M, Dadic R, Meyer H, Werner M, Brunello CF, Jafari M, Wever N, Arndt S, Krampe D, Sturm M, Schneebeli M.   +11 more
europepmc   +1 more source

Spatial characteristics of accumulation patterns derived from combined data sets on Amundsenisen plateau, Antarctica [PDF]

, 2003
Eisen, Olaf, Miller, Heinrich, Nixdorf, Uwe, Rotschky, G., Steinhage, Daniel   +4 more
core  

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Shifting winter atmospheric teleconnections to the North Pacific reconcile Younger-Dryas and Holocene δ¹⁸O signals. [PDF]

Nat Commun
Anderson L, Finney BP, Baxter WB.
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Analyzing Pathophysiology and Immune Cells and Their Cytokines and Mediators in Precision-Cut Slices of the Murine Lung. [PDF]

Curr Protoc
Tatcheff M, Carvalho C, Willar J, Nendel E, Krammer S, Chiriac MT, Zhou S, Geppert CI, Finotto S.   +8 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Pan-Arctic Peatlands Have Expanded During Recent Warming. [PDF]

Glob Chang Biol
Handley J, Fewster RE, Sim TG, Hodson S, Parker B, Crichton K, Charman D, Anderson K, Garneau M, Väliranta M, Beilman DW, Swindles GT, Aquino-López M, Blaauw M, Comas X, Levesque E, Maire V, Addis H, Amesbury M, Fortier D, Mleczko M, Gallego-Sala A.   +21 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Photosynthetic light requirement near the theoretical minimum detected in Arctic microalgae. [PDF]

Nat Commun
Hoppe CJM, Fuchs N, Notz D, Anderson P, Assmy P, Berge J, Bratbak G, Guillou G, Kraberg A, Larsen A, Lebreton B, Leu E, Lucassen M, Müller O, Oziel L, Rost B, Schartmüller B, Torstensson A, Wloka J.   +18 more
europepmc   +1 more source