Results 241 to 250 of about 3,234 (297)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Lacustrine sedimentation patterns at the Northern Antarctic Peninsula and surroundings as a response to late Holocene and Modern Climate changes. [PDF]

Sci Rep
Evangelista H, Verkulich S, Mavlyudov B, Souza Echer MP, Licinio MV, Dercon G, García-Rodríguez F, Neto AA, Kusch S, Abuchacra RC, Oaquim ABJ, Gonçalves SJ, Pushina Z, Shimizu MH, Heiling M, Slaets J, Resch C, Castillo A, Gruber R.   +18 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Microbial succession and hydrocarbon-degrading potential in Arctic sea ice exposed to dispersed crude oil and chemical dispersant. [PDF]

FEMS Microbes
Nõlvak H, Dang NP, Truu M, Peeb A, Devarajan AK, Petrich C, O'Sadnick M, Tiirik K, Truu J.   +8 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Mercury records from natural archives reveal ecosystem responses to changing atmospheric deposition. [PDF]

Natl Sci Rev
Chen Q, Wu Q, Cui Y, Wang S.
europepmc   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

Oligocene deep ocean oxygen isotope variations primarily driven by temperature. [PDF]

Nat Geosci
Boscolo-Galazzo F, Taylor VE, Galaasen EV, Liebrand D, Gasson E, Dallanave E, Fernandez-Bremer A, Witkowski J, Bohaty SM, Meckler AN.   +9 more
europepmc   +1 more source

Early Holocene Quantitative Summer Temperature Reconstructions in SE Lithuania Inferred from Chironomidae Data. [PDF]

Biology (Basel)
Gastevičienė N, Kluczynska G, Šeirienė V.   +2 more
europepmc   +1 more source

Neglecting organic alkalinity introduces greater error than assuming boron to salinity ratios in Arctic sea ice brine carbonate system calculations. [PDF]

Sci Rep
Rush S, Lee CH, Lee K, Yoon SH, Vlahos P.   +4 more
europepmc   +1 more source