Results 101 to 110 of about 663,567 (291)

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Ice-Sheet Imaging near an Antarctic Drilling Site Using Passive Seismic Rayleigh Waves and P-Wave Reflections

Remote Sensing
Antarctic drilling projects provide critical information for investigating ice-sheet stability, reconstructing paleoclimate evolution, and characterizing subglacial geological structures through ice-core and bedrock recovery.
Jun Zheng, Guofeng Liu, Yazhou Li, Bing Li, Yuchen Sun   +4 more
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Brief communication: RADIX (Rapid Access Drilling and Ice eXtraction) dust logger test in the EastGRIP (East Greenland Ice-core Project) hole [PDF]

The Cryosphere
The RADIX (Rapid Access Drilling and Ice eXtraction) optical dust logger is part of the exploratory drilling system developed at the University of Bern.
J. Schwander, J. Schwander, T. F. Stocker, T. F. Stocker, R. Walther, R. Walther, S. Marending, S. Marending, T. Erhardt, T. Erhardt, T. Erhardt, C. Zeppenfeld, C. Zeppenfeld, J. Jost   +13 more
doaj   +1 more source

Proceedings of the Integrated Ocean Drilling Program 337: Deep Coalbed Biosphere off Shimokita

, 2013
<p>Integrated Ocean Drilling Program (IODP) Expedition 337 was the first expedition dedicated to subseafloor microbiology that used riser drilling technology.
Lever, Mark A., Park, Young Soo, Riedinger, Natascha, Hong, Wei Li, Heuer, Verena B., Sanada, Yoshinori, Harrington, G.J., Susilawati, Rita, Morita, Sumito, Kubo, Yusuke, Hori, Tomoyuki, Morono, Yuki, Glombitza, Clemens, Phillips, Stephen C., Lin, Yu Shih, Bowden, Stephen A., Bowles, Marshall, Limmer, David, Snyder, Glen, Hoshino, Tatsuhiko, Sauvage, Justine, Hinrichs, Kai-Uwe, Tanikawa, Wataru, Reischenbacher, Doris, Ijiri, Akira, Inagaki, Fumio, Liu, Changhong, Murayama, Masafumi, Yamada, Yasuhiro, Trembath-Reichert, Elizabeth   +29 more
core   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Spontaneous Cyclic Levitation of Glycerol‐Water Droplets at Low Pressures

Advanced Science, EarlyView.
Under low pressure, a minute glycerol addition transforms the chaotic dynamics of freezing water droplets into cyclic levitation. Freeze‐concentration preserves liquid pathways that relax expansion‐induced stress, while freezing point depression weakens asymmetric vaporization recoil.
Chen Xu, Renjie Hua, Wei Ma, Fuqiang Chu, Dong Liang, Xueshi Li, Qirui Zhang, Yuan Dong, Xuehu Ma, Xiao Yan, Shuhuai Yao   +10 more
wiley   +1 more source

Ice core hot-flid drilling

Antarctic Record, 1994
Fast hole production is possible using ice core hot-fluid drilling. The present paper describes a method for calculation of drill penetration rate dependent on the fluid flux, fluid temperature, physical properties of fluid, size of hot-fluid drill head and properties of ice.
B.B., Kudryashov, N.G., Menshikov
openaire   +2 more sources

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source