Results 91 to 100 of about 663,567 (291)

Proceedings of the Integrated Ocean Drilling Program 303/306: North Atlantic Climate

open access: yes, 2006
<p>Expedition 303 was designed to sample and study strategic sites that record components of North Atlantic Pliocene–Quaternary climate, including the composition and structure of surface or bottom waters and detrital-layer stratigraphy ...
Shimada, Chieko   +54 more
core   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

open access: yesAdvanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu   +11 more
wiley   +1 more source

Ice core drilling on the southern slope of the Nepal Himalayas [PDF]

open access: yes, 2002
P(論文)Two ice cores were extracted from Rikha Samba Glacier located in the central Nepal Himalayas in 1994 and 1998. Ice core quality in 1994 was poor due to cutter problems and samples were melted in situ.
Takeuchi, Nozomu   +6 more
core  

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang   +18 more
wiley   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

open access: yesAdvanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li   +12 more
wiley   +1 more source

Activities of the Dome Fuji Station wintering party of the 44th Japanese Antarctic Research Expedition in 2003-2004

open access: yesAntarctic Record, 2005
The 44th Dome Fuji Wintering party, consisting of eight personnel, carried out observation and logistic works at Dome Fuji Station (77°19S, 39°42E, 3810m a.s.l.) from 19 January 2003 to 23 January 2004.
Ichio Obinata
doaj   +1 more source

Dome Argus: Ideal site for deep ice drilling [PDF]

open access: yes, 2012
Located on the centre of ice drainage range, the highest Dome Argus (Dome A) of East Antarctic Ice Sheet (EAIS), could be represented as an ideal site for deep ice cores drilling containing oldest paleo-climate records. To select a suitable drilling site
Yuansheng, Li   +3 more
core   +1 more source

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

open access: yesAdvanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li   +16 more
wiley   +1 more source

Numerical Investigation of Drilling Process for Complex Polar Ice Interlayers: An F-DEM Study

open access: yesApplied Sciences
Subglacial drilling through polar ice–rock transitional zones is frequently hindered by severe load fluctuations and instability induced by strong formation heterogeneity.
Zongjie Mu   +7 more
doaj   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

open access: yesAdvanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng   +12 more
wiley   +1 more source

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