Results 121 to 130 of about 804,547 (290)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Performance Evaluation of Different Speech-Based Emotional Stress Level Detection Approaches

IEEE Access
This study presents a comprehensive evaluation and comparison of selected conventional and advanced approaches for detecting and classifying emotional stress levels from speech.
Jan Stas, Stanislav Ondas, Jozef Juhar
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Recovery of Water and Salt from Hyper-Saline Mine Water using Freeze Crystallization [PDF]

, 2019
The Freezerbacks researched, designed, and economically evaluated a full-scale freeze crystallization process as well as two alternative full-scale processes: 5 stage multiple effect evaporation and reverse osmosis.
Casey, Gabrielle
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Contamination Detection From Highly Cluttered Waste Scenes Using Computer Vision

IEEE Access
As the global production of waste continues to rise, there is a growing demand for more effective waste management strategies to handle this expanding problem.
Dishant Mewada, Cathaoir Agnew, Eoin M. Grua, Ciaran Eising, Patrick Denny, Mark Heffernan, Ken Tierney, Pepijn van de Ven, Anthony Scanlan   +8 more
doaj   +1 more source

Cold Starting of IC Engines

Defence Science Journal, 1988
Studies of cold starting of IC engines carried out at Indian Institute of Petroleum (IIP) and field trials at high altitudes under sub-zero temperature conditions are described in this paper. Different operating factors influencing the cold starting of diesel engines and the role of starting aids developed at IIP have also been described.
openaire   +1 more source

North Slope Borough water study: a background for planning [PDF]

, 1977
The Planning and Research Section of Alaska Dept. of Natural Resources initiated this pilot water study with the North Slope Borough and the University of Alaska's Arctic Environmental Information and Data Center and Institute of Water Resources ...
Dreyer, Linda Dwight, Johnson, Ronald A.
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source