Results 101 to 110 of about 199,393 (317)

An automatic multi-stepping approach to aircraft ice prediction [PDF]

, 2007
Flying an aircraft in icing conditions may seriously degrade its aerodynamical performance and threaten the flight safety. Over the years, new technologies and improved procedures have limited the potential risks caused by aircraft icing. Experimental
Verdin, Patrick G.
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Tunable macroscale structural superlubricity in two-layer graphene via strain engineering

Nature Communications, 2020
Superlubricity in macro-scale graphitic samples is hampered by commensurate stacking domains that prevent facile sliding between adjacent graphene layers.
Charalampos Androulidakis, Emmanuel N. Koukaras, George Paterakis, George Trakakis, Costas Galiotis   +4 more
doaj   +1 more source

Ice basin tests for ice-induced vibrations of offshore structures in the SHIVER project

, 2022
With the recent surge in development of offshore wind in the Baltic Sea, Bohai Sea and other ice-prone regions, a need has arisen for new basin tests to qualify the interaction between offshore wind turbines and sea ice.
van den Berg, M.A. (author), Hendrikse, H. (author), van den Berg, M.A., Hammer, T.C. (author), Hendrikse, Hayo, Owen, C.C. (author), van den Berg, Marnix, van Beek, Kees, van Beek, C. (author), Puolakka, Otto (author), Owen, C.C., Polojärvi, Arttu, Puolakka, Otto, Polojärvi, Arttu (author), Owen, Cody, Willems, Tom (author), Hendrikse, H., Willems, Tom, Hammer, Tim, Hammer, T.C., van Beek, C.   +20 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Increasing the flexural strength of columnar-grained ice by an icy coating

Journal of Glaciology
New experiments have revealed that a thin layer of granular ice bonded to salty and to salt-free columnar-grained ice increases flexural strength when the composite material is rapidly bent to the point of failure through brittle fracture.
David Edington, Andrii Murdza, Erland M. Schulson   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Flexural behavior of porous isotropic ice under three-point bending tests

Journal of Glaciology
Understanding ice flexural behavior is essential for assessing interactions with structures in cold environments. The mechanical response of ice depends on microstructural properties, such as grain size and porosity, which vary widely in natural ice ...
David Georges, Maurine Montagnat, Pascal Forquin, Dominique Saletti, Hubert Maigre   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source