Results 81 to 90 of about 5,217,857 (291)
Fracture of warm columnar freshwater ice : Thickness effect
Publisher Copyright: © 2024, International Association for Hydro-Environment Engineering and Research. All rights reserved.The behavior of ice is influenced by numerous variables, including temperature, scale, loading rate, and microstructural properties
El Gharamti, Iman +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Increasing the flexural strength of columnar-grained ice by an icy coating
Journal of GlaciologyNew experiments have revealed that a thin layer of granular ice bonded to salty and to salt-free columnar-grained ice increases flexural strength when the composite material is rapidly bent to the point of failure through brittle fracture.
David Edington +2 more
doaj +1 more source
Tunable macroscale structural superlubricity in two-layer graphene via strain engineering
Nature Communications, 2020 Superlubricity in macro-scale graphitic samples is hampered by commensurate stacking domains that prevent facile sliding between adjacent graphene layers.
Charalampos Androulidakis +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Flexural behavior of porous isotropic ice under three-point bending tests
Journal of GlaciologyUnderstanding ice flexural behavior is essential for assessing interactions with structures in cold environments. The mechanical response of ice depends on microstructural properties, such as grain size and porosity, which vary widely in natural ice ...
David Georges +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Low-Cost Multifunctional Assistive Device for Visually Impaired Individuals
IEEE AccessVisually impaired individuals face challenges in mobility, object recognition, and text reading. Existing assistive tools provide partial solutions but lack full integration. This paper presents a low-cost, multifunctional assistive device in the form of
Richard Kral, Patrik Jacko, Tibor Vince
doaj +1 more source
Ice pressure on engineering structures
, 2020 1 Îli-Blb y (Jjk co LD Région s / C I E N C E A N D E N G I N E E R I N G -M-o-n^gra ph TIT- B 1 b ) ICE PRESSURE ON ENGINEERING STRUCTURES Bernard Michel June 1970 GB 2401 .U58m Ill-Bib 1970 CORPS OF ENGINEERS, U.S.
Cold Regions Research and Engineering Laboratory (U.S.)
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source