Results 71 to 80 of about 5,217,857 (291)
Eulerian method for ice crystal icing in turbofan engines [PDF]
, 2017 The newer generations of high-bypass-ratio engines are susceptible to the ingestion of small ice crystals which may cause engine power loss or damage. The research presented in this thesis focusses on the development of a computational method for in-engine ice crystal accretion.
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pressure drop of flowing ice slurries in industrial heat exchangers [PDF]
, 2009 Experiments were conducted to determine the characteristics of ice flows through industrial heat exchangers (a Tetra Plex (R) C6-SR and a Tetra Spiraflo (R) MTC70/W-3).
Quarini, G.L. +8 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Salinity-controlled laboratory production of ice
Publisher Copyright: © 2024, International Association for Hydro-Environment Engineering and Research. All rights reserved.A 2 m by 4 m basin was constructed to grow saline ice.
Oksala, Sid +3 more
core +1 more source
Wyoming Silver Jackets River Ice Workshop CRREL ice engineering introduction
, 2022 Wyoming Silver JacketsRiver Ice WorkshopCRREL Ice Engineering Introduction CRREL Ice Engineering Group Presented by, Joseph Rocks Research Hydraulic Engineer ERDC Cold Regions Research and Engineering Laboratory, Hanover, NH May 2018Innovative solutions ...
Engineer Research and Development Center (U.S.); United States. Army. Corps of Engineers; Cold Regions Research and Engineering Laboratory (U.S.);
core
Autosub6000: a deep diving long range AUV [PDF]
, 2008 With an ultimate range up to 1000 km, a maximum operating depth of 6000 m, and a generous payload capacity, Autosub6000 is well placed to become one of the world's most capable deep diving Autonomous Underwater Vehicles (AUVs).
McPhail, Stephen
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source