Results 251 to 260 of about 47,826 (311)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

The principles of systems biology. [PDF]

Exp Physiol
Noble D, Bourret R.
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Determination of factors that allow cryogenic nanoscopy with high power illumination without devitrification. [PDF]

PLoS One
Huebinger J, Bastiaens PIH.
europepmc   +1 more source

Model simulations capture seasonal Arctic Haze and clean-air cycle better than satellite and reanalysis. [PDF]

Sci Rep
Swain B, Vountas M, Singh A, Song R, Panda U, Schellhorn H, Andrae L, Deroubaix A, Lelli L, Tandon A, Nikumbh A, Gunthe SS.   +11 more
europepmc   +1 more source

Particular Water Organization in Homogeneous Water Mixtures of Amphiphilic Polystyrene-<i>block</i>-poly(methoxydiethylene glycol acrylate) Diblock Copolymer with Thermoresponsive Behavior. [PDF]

J Phys Chem B
Kripotou S, Manochis A, Miasnikova A, Laschewsky A, Papadakis CM, Kyritsis A.   +5 more
europepmc   +1 more source

Mercury accumulation over the Holocene revealed from a Greenlandic ice core. [PDF]

Sci Adv
Gao Z, Oliveira R, Feinberg A, Segato D, Saiz-Lopez A, Armstrong D, Spolaor A, Kjær HA, Steffensen JP, Barbante C, Dahl-Jensen D, Wang F.   +11 more
europepmc   +1 more source

Model evidence for distinct origins of glacial-interglacial and millennial signals in Greenland dust. [PDF]

Proc Natl Acad Sci U S A
Hopcroft PO, Rousseau DD.
europepmc   +1 more source

Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels.

Mater Horiz
Wu J, Jiang P, Yang X, Bai C, Miao Z, Wang Y, Zhang H, Wang X.   +7 more
europepmc   +1 more source