Results 181 to 190 of about 72,753 (311)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Late Pliocene growth of the West Antarctic Ice Sheet to near-modern configuration. [PDF]

Nat Commun
Rahaman W, Gutjahr M, Prabhat P.
europepmc   +1 more source

Contemporary ice sheet thinning drives subglacial groundwater exfiltration with potential feedbacks on glacier flow. [PDF]

Sci Adv, 2023
Robel AA, Sim SJ, Meyer C, Siegfried MR, Gustafson CD.   +4 more
europepmc   +1 more source

Thinning of the Ice Sheet in Mizuho Plateau, East Antarctica [PDF]

, 1979
Renji Naruse
openalex   +1 more source

Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells

Advanced Science, EarlyView.
In this study, it is shown that 1‐day co‐culture with activated T cells or IL‐2‐presenting synthetic cells significantly enhances NK cell motility and cytotoxicity in 2D and 3D. Notably, synthetic cells restore the impaired cytotoxic function of cryopreserved NK and CAR‐NK cells in 3D.
Xiangda Zhou, Sijia Zhang, Wenjuan Yang, Susanne Gonder, Zeinab Sadjadi, Nils Piernitzki, Alina Moter, Shulagna Sharma, Anne Largeot, Nadja Küchler, Lea Kaschek, Gertrud Schäfer, Eva C. Schwarz, Hermann Eichler, Evelyn Ullrich, Heiko Rieger, Oskar Staufer, Jérôme Paggetti, Etienne Moussay, Markus Hoth, Bin Qu   +20 more
wiley   +1 more source

Southern Ocean evidence for recurring West Antarctic Ice Sheet destabilization during Marine Isotope Stage 11. [PDF]

Nat Commun
Jebasinski L, Frick DA, Kapuge AKIU, Basak C, Saavedra-Pellitero M, Winckler G, Lamy F, Gottschalk J.   +7 more
europepmc   +1 more source

Economic impacts of melting of the Antarctic Ice Sheet. [PDF]

Nat Commun, 2022
Dietz S, Koninx F.
europepmc   +1 more source

Theory of Deformations within Ice Sheets due to Bottom Undulations [PDF]

, 1979
S. J. Johnsen, Kjeld Rasmussen, Niels Reeh   +2 more
openalex   +1 more source

MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota

Advanced Science, EarlyView.
Herbal medicine, with its multicomponent and multitarget potential, is often studied primarily for traditional forms, especially phytochemicals. Currently, ulcerative colitis lacks natural, low‐toxicity therapies, yet emerging research highlights plant‐derived exosomes as a promising option.
Ruipeng Shi, Wen Tan, Haochun Jin, Sio I Chan, Wei Li, Si San Lei, Guozhen Cui, Yitao Wang, Dong‐Hua Yang, Zhangfeng Zhong   +9 more
wiley   +1 more source

Linking extreme light availability to cellular function in algae-dominated communities on the Greenland Ice Sheet. [PDF]

FEMS Microbiol Ecol
Feord HK, Keuschnig C, Trivedi CB, Mourot R, Zervas A, Turpin-Jelfs T, Tranter M, Anesio AM, Adrian L, Benning LG.   +9 more
europepmc   +1 more source